TY  - JOUR
AU  - Myung, Jin Suk
AU  - Roosen-Runge, Felix
AU  - Winkler, Roland G.
AU  - Gompper, Gerhard
AU  - Schurtenberger, Peter
AU  - Stradner, Anna
TI  - Weak Shape Anisotropy Leads to a Nonmonotonic Contribution to Crowding, Impacting Protein Dynamics under Physiologically Relevant Conditions
JO  - The journal of physical chemistry  / B B, Condensed matter, materials, surfaces, interfaces & biophysical
VL  - 122
IS  - 51
SN  - 1520-5207
CY  - Washington, DC
PB  - Soc.66306
M1  - FZJ-2018-07469
SP  - 12396-12402
PY  - 2018
AB  - The effect of a nonspherical particle shape on the dynamics in crowded solutions presents a significant challenge for a comprehensive understanding of interaction and structural relaxation in biological and soft matter. We report that small deviations from a spherical shape induce a nonmonotonic contribution to the crowding effect on the short-time cage diffusion compared with spherical systems, using molecular dynamics simulations with mesoscale hydrodynamics of a multiparticle collision dynamics fluid in semidilute systems with volume fractions smaller than 0.35. We show that the nonmonotonic effect due to anisotropy is caused by the combination of a reduced relative mobility over the entire concentration range and a looser and less homogeneous cage packing of nonspherical particles. Our finding stresses that nonsphericity induces new complexity, which cannot be accounted for in effective sphere models, and is of great interest in applications such as formulations as well as for the fundamental understanding of soft matter in general and crowding effects in living cells in particular.
LB  - PUB:(DE-HGF)16
C6  - pmid:30499666
UR  - <Go to ISI:>//WOS:000454751400016
DO  - DOI:10.1021/acs.jpcb.8b07901
UR  - https://juser.fz-juelich.de/record/858609
ER  -