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@ARTICLE{Myung:858609,
      author       = {Myung, Jin Suk and Roosen-Runge, Felix and Winkler, Roland
                      G. and Gompper, Gerhard and Schurtenberger, Peter and
                      Stradner, Anna},
      title        = {{W}eak {S}hape {A}nisotropy {L}eads to a {N}onmonotonic
                      {C}ontribution to {C}rowding, {I}mpacting {P}rotein
                      {D}ynamics under {P}hysiologically {R}elevant {C}onditions},
      journal      = {The journal of physical chemistry / B B, Condensed matter,
                      materials, surfaces, interfaces $\&$ biophysical},
      volume       = {122},
      number       = {51},
      issn         = {1520-5207},
      address      = {Washington, DC},
      publisher    = {Soc.66306},
      reportid     = {FZJ-2018-07469},
      pages        = {12396-12402},
      year         = {2018},
      abstract     = {The effect of a nonspherical particle shape on the dynamics
                      in crowded solutions presents a significant challenge for a
                      comprehensive understanding of interaction and structural
                      relaxation in biological and soft matter. We report that
                      small deviations from a spherical shape induce a
                      nonmonotonic contribution to the crowding effect on the
                      short-time cage diffusion compared with spherical systems,
                      using molecular dynamics simulations with mesoscale
                      hydrodynamics of a multiparticle collision dynamics fluid in
                      semidilute systems with volume fractions smaller than 0.35.
                      We show that the nonmonotonic effect due to anisotropy is
                      caused by the combination of a reduced relative mobility
                      over the entire concentration range and a looser and less
                      homogeneous cage packing of nonspherical particles. Our
                      finding stresses that nonsphericity induces new complexity,
                      which cannot be accounted for in effective sphere models,
                      and is of great interest in applications such as
                      formulations as well as for the fundamental understanding of
                      soft matter in general and crowding effects in living cells
                      in particular.},
      cin          = {IAS-2},
      ddc          = {530},
      cid          = {I:(DE-Juel1)IAS-2-20090406},
      pnm          = {553 - Physical Basis of Diseases (POF3-553)},
      pid          = {G:(DE-HGF)POF3-553},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30499666},
      UT           = {WOS:000454751400016},
      doi          = {10.1021/acs.jpcb.8b07901},
      url          = {https://juser.fz-juelich.de/record/858609},
}