% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Ni:858623,
      author       = {Ni, Guiyan and Moser, Gerhard and Wray, Naomi R and Lee, S
                      Hong and Ripke, Stephan and Neale, Benjamin M and Corvin,
                      Aiden and Walters, James T R and Farh, Kai-How and Holmans,
                      Peter A and Lee, Phil and Bulik-Sullivan, Brendan and
                      Collier, David A and Huang, Hailiang and Pers, Tune H and
                      Agartz, Ingrid and Agerbo, Esben and Albus, Margot and
                      Alexander, Madeline and Amin, Farooq and Bacanu, Silviu A
                      and Begemann, Martin and Belliveau, Richard A and Bene,
                      Judit and Bergen, Sarah E and Bevilacqua, Elizabeth and
                      Bigdeli, Tim B and Black, Donald W and Bruggeman, Richard
                      and Buccola, Nancy G and Buckner, Randy L and Byerley,
                      William and Cahn, Wiepke and Cai, Guiqing and Campion,
                      Dominique and Cantor, Rita M and Carr, Vaughan J and
                      Carrera, Noa and Catts, Stanley V and Chambert, Kimberly D
                      and Chan, Raymond C K and Chen, Ronald Y L and Chen, Eric Y
                      H and Cheng, Wei and Cheung, Eric F C and Chong, Siow Ann
                      and Cloninger, C Robert and Cohen, David and Cohen, Nadine
                      and Cormican, Paul and Craddock, Nick and Crowley, James J
                      and Curtis, David and Davidson, Michael and Davis, Kenneth L
                      and Degenhardt, Franziska and Del Favero, Jurgen and
                      Demontis, Ditte and Dikeos, Dimitris and Dinan, Timothy and
                      Djurovic, Srdjan and Donohoe, Gary and Drapeau, Elodie and
                      Duan, Jubao and Dudbridge, Frank and Durmishi, Naser and
                      Eichhammer, Peter and Eriksson, Johan and Escott-Price,
                      Valentina and Essioux, Laurent and Fanous, Ayman H and
                      Farrell, Martilias S and Frank, Josef and Franke, Lude and
                      Freedman, Robert and Freimer, Nelson B and Friedl, Marion
                      and Friedman, Joseph I and Fromer, Menachem and Genovese,
                      Giulio and Georgieva, Lyudmila and Giegling, Ina and
                      Giusti-Rodríguez, Paola and Godard, Stephanie and
                      Goldstein, Jacqueline I and Golimbet, Vera and Gopal,
                      Srihari and Gratten, Jacob and de Haan, Lieuwe and Hammer,
                      Christian and Hamshere, Marian L and Hansen, Mark and
                      Hansen, Thomas and Haroutunian, Vahram and Hartmann, Annette
                      M and Henskens, Frans A and Herms, Stefan and Hirschhorn,
                      Joel N and Hoffmann, Per and Hofman, Andrea and Hollegaard,
                      Mads V and Hougaard, David M and Ikeda, Masashi and Joa,
                      Inge and Juliá, Antonio and Kahn, René S and Kalaydjieva,
                      Luba and Karachanak-Yankova, Sena and Karjalainen, Juha and
                      Kavanagh, David and Keller, Matthew C and Kennedy, James L
                      and Khrunin, Andrey and Kim, Yunjung and Klovins, Janis and
                      Knowles, James A and Konte, Bettina and Kucinskas, Vaidutis
                      and Kucinskiene, Zita Ausrele and Kuzelova-Ptackova, Hana
                      and Kähler, Anna K and Laurent, Claudine and Keong, Jimmy
                      Lee Chee and Legge, Sophie E and Lerer, Bernard and Li,
                      Miaoxin and Li, Tao and Liang, Kung-Yee and Lieberman,
                      Jeffrey and Limborska, Svetlana and Loughland, Carmel M and
                      Lubinski, Jan and Lönnqvist, Jouko and Macek, Milan and
                      Magnusson, Patrik K E and Maher, Brion S and Maier, Wolfgang
                      and Mallet, Jacques and Marsal, Sara and Mattheisen, Manuel
                      and Mattingsda, Morten and McCarley, Robert W and McDonald,
                      Colm and McIntosh, Andrew M and Meier, Sandra and Meijer,
                      Carin J and Melegh, Bela and Melle, Ingrid and
                      Mesholam-Gately, Raquelle I and Metspalu, Andres and Michie,
                      Patricia T and Milani, Lili and Milanova, Vihra and Mokrab,
                      Younes and Morris, Derek W and Mors, Ole and Murphy, Kieran
                      C and Murray, Robin M and Myin-Germeys, Inez and
                      Müller-Myhsok, Bertram and Nelis, Mari and Nenadic, Igor
                      and Nertney, Deborah A and Nestadt, Gerald and Nicodemus,
                      Kristin K and Nikitina-Zake, Liene and Nisenbaum, Laura and
                      Nordin, Annelie and O'Callaghan, Eadbhard and O'Dushlaine,
                      Colm and O'Neill, F Anthony and Oh, Sang-Yun and Olinc, Ann
                      and Olsen, Line and Van Os, Jim and Pantelis, Christos and
                      Papadimitriou, George N and Papio, Sergi and Parkhomenko,
                      Elena and Pato, Michele T and Paunio, Tiina and
                      Pejovic-Milovancevic, Milica and Perkins, Diana O and
                      Pietiläinenl, Olli and Pimm, Jonathan and Pocklington,
                      Andrew J and Powell, John and Price, Alkes and Pulver, Ann E
                      and Purcell, Shaun M and Quested, Digby and Rasmussen,
                      Henrik B and Reichenberg, Abraham and Reimers, Mark A and
                      Richards, Alexander L and Roffman, Joshua L and Roussos,
                      Panos and Ruderfer, Douglas M and Salomaa, Veikko and
                      Sanders, Alan R and Schall, Ulrich and Schubert, Christian R
                      and Schulze, Thomas G and Schwab, Sibylle G and Scolnick,
                      Edward M and Scott, Rodney J and Seidman, Larry J and Shi,
                      Jianxin and Sigurdsson, Engilbert and Silagadze, Teimuraz
                      and Silverman, Jeremy M and Sim, Kang and Slominsky, Petr
                      and Smoller, Jordan W and So, Hon-Cheong and Spencer, Chris
                      C A and Stah, Eli A and Stefansson, Hreinn and Steinberg,
                      Stacy and Stogmann, Elisabeth and Straub, Richard E and
                      Strengman, Eric and Strohmaier, Jana and Stroup, T Scott and
                      Subramaniam, Mythily and Suvisaari, Jaana and Svrakic,
                      Dragan M and Szatkiewicz, Jin P and Söderman, Erik and
                      Thirumalai, Srinivas and Toncheva, Draga and Tosato, Sarah
                      and Veijola, Juha and Waddington, John and Walsh, Dermot and
                      Wang, Dai and Wang, Qiang and Webb, Bradley T and Weiser,
                      Mark and Wildenauer, Dieter B and Williams, Nigel M and
                      Williams, Stephanie and Witt, Stephanie H and Wolen, Aaron R
                      and Wong, Emily H M and Wormley, Brandon K and Xi, Hualin
                      Simon and Zai, Clement C and Zheng, Xuebin and Zimprich,
                      Fritz and Stefansson, Kari and Visscher, Peter M and
                      Adolfsson, Rolf and Andreassen, Ole A and Blackwood, Douglas
                      H R and Bramon, Elvira and Buxbaum, Joseph D and Børglum,
                      Anders D and Cichon, Sven and Darvasi, Ariel and Domenici,
                      Enrico and Ehrenreich, Hannelore and Esko, Tõnu and Gejman,
                      Pablo V and Gill, Michael and Gurling, Hugh and Hultman,
                      Christina M and Iwata, Nakao and Jablensky, Assen V and
                      Jönsson, Erik G and Kendler, Kenneth S and Kirov, George
                      and Knight, Jo and Lencz, Todd and Levinson, Douglas F and
                      Li, Qingqin S and Liu, Jianjun and Malhotra, Anil K and
                      McCarrol, Steven A and McQuillin, Andrew and Moran, Jennifer
                      L and Mortensen, Preben B and Mowry, Bryan J and Nöthen,
                      Markus M and Ophoff, Roel A and Owen, Michael J and Palotie,
                      Aarno and Pato, Carlos N and Petryshen, Tracey L and
                      Posthuma, Danielle and Rietsche, Marcella and Riley, Brien P
                      and Rujescu, Dan and Sham, Pak C and Sklar, Pamela and St
                      Clair, David and Weinberger, Daniel R and Wendland, Jens R
                      and Werge, Thomas and Daly, Mark J and Sullivan, Patrick F
                      and O'Donovan, Michael C},
      title        = {{E}stimation of {G}enetic {C}orrelation via {L}inkage
                      {D}isequilibrium {S}core {R}egression and {G}enomic
                      {R}estricted {M}aximum {L}ikelihood.},
      journal      = {The American journal of human genetics},
      volume       = {102},
      number       = {6},
      issn         = {0002-9297},
      address      = {New York, NY},
      publisher    = {Elsevier},
      reportid     = {FZJ-2018-07483},
      pages        = {1185 - 1194},
      year         = {2018},
      abstract     = {Genetic correlation is a key population parameter that
                      describes the shared genetic architecture of complex traits
                      and diseases. It can be estimated by current state-of-art
                      methods, i.e., linkage disequilibrium score regression
                      (LDSC) and genomic restricted maximum likelihood (GREML).
                      The massively reduced computing burden of LDSC compared to
                      GREML makes it an attractive tool, although the accuracy
                      (i.e., magnitude of standard errors) of LDSC estimates has
                      not been thoroughly studied. In simulation, we show that the
                      accuracy of GREML is generally higher than that of LDSC.
                      When there is genetic heterogeneity between the actual
                      sample and reference data from which LD scores are
                      estimated, the accuracy of LDSC decreases further. In real
                      data analyses estimating the genetic correlation between
                      schizophrenia (SCZ) and body mass index, we show that GREML
                      estimates based on ∼150,000 individuals give a higher
                      accuracy than LDSC estimates based on ∼400,000 individuals
                      (from combined meta-data). A GREML genomic partitioning
                      analysis reveals that the genetic correlation between SCZ
                      and height is significantly negative for regulatory regions,
                      which whole genome or LDSC approach has less power to
                      detect. We conclude that LDSC estimates should be carefully
                      interpreted as there can be uncertainty about homogeneity
                      among combined meta-datasets. We suggest that any
                      interesting findings from massive LDSC analysis for a large
                      number of complex traits should be followed up, where
                      possible, with more detailed analyses with GREML methods,
                      even if sample sizes are lesser.},
      cin          = {INM-1},
      ddc          = {570},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      pmc          = {pmc:PMC5993419},
      UT           = {WOS:000434946200014},
      doi          = {10.1016/j.ajhg.2018.03.021},
      url          = {https://juser.fz-juelich.de/record/858623},
}