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000858742 1001_ $$0P:(DE-HGF)0$$aSánchez-López, Carolina$$b0
000858742 245__ $$aStructural Determinants of the Prion Protein N-Terminus and Its Adducts with Copper Ions
000858742 260__ $$aBasel$$bMolecular Diversity Preservation International$$c2019
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000858742 520__ $$aThe N-terminus of the prion protein is a large intrinsically disordered region encompassing approximately 125 amino acids. In this paper, we review its structural and functional properties, with a particular emphasis on its binding to copper ions. The latter is exploited by the region’s conformational flexibility to yield a variety of biological functions. Disease-linked mutations and proteolytic processing of the protein can impact its copper-binding properties, with important structural and functional implications, both in health and disease progression.
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000858742 7001_ $$0P:(DE-Juel1)145921$$aRossetti, Giulia$$b1
000858742 7001_ $$0P:(DE-HGF)0$$aQuintanar, Liliana$$b2$$eCorresponding author
000858742 7001_ $$0P:(DE-Juel1)145614$$aCarloni, Paolo$$b3$$eCorresponding author
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