TY  - JOUR
AU  - Sánchez-López, Carolina
AU  - Rossetti, Giulia
AU  - Quintanar, Liliana
AU  - Carloni, Paolo
TI  - Structural Determinants of the Prion Protein N-Terminus and Its Adducts with Copper Ions
JO  - International journal of molecular sciences
VL  - 20
IS  - 1
SN  - 1422-0067
CY  - Basel
PB  - Molecular Diversity Preservation International
M1  - FZJ-2018-07587
SP  - 18
PY  - 2019
AB  - The N-terminus of the prion protein is a large intrinsically disordered region encompassing approximately 125 amino acids. In this paper, we review its structural and functional properties, with a particular emphasis on its binding to copper ions. The latter is exploited by the region’s conformational flexibility to yield a variety of biological functions. Disease-linked mutations and proteolytic processing of the protein can impact its copper-binding properties, with important structural and functional implications, both in health and disease progression.
LB  - PUB:(DE-HGF)16
C6  - pmid:30577569
UR  - <Go to ISI:>//WOS:000459747700018
DO  - DOI:10.3390/ijms20010018
UR  - https://juser.fz-juelich.de/record/858742
ER  -