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@ARTICLE{SnchezLpez:858742,
      author       = {Sánchez-López, Carolina and Rossetti, Giulia and
                      Quintanar, Liliana and Carloni, Paolo},
      title        = {{S}tructural {D}eterminants of the {P}rion {P}rotein
                      {N}-{T}erminus and {I}ts {A}dducts with {C}opper {I}ons},
      journal      = {International journal of molecular sciences},
      volume       = {20},
      number       = {1},
      issn         = {1422-0067},
      address      = {Basel},
      publisher    = {Molecular Diversity Preservation International},
      reportid     = {FZJ-2018-07587},
      pages        = {18},
      year         = {2019},
      abstract     = {The N-terminus of the prion protein is a large
                      intrinsically disordered region encompassing approximately
                      125 amino acids. In this paper, we review its structural and
                      functional properties, with a particular emphasis on its
                      binding to copper ions. The latter is exploited by the
                      region’s conformational flexibility to yield a variety of
                      biological functions. Disease-linked mutations and
                      proteolytic processing of the protein can impact its
                      copper-binding properties, with important structural and
                      functional implications, both in health and disease
                      progression.},
      cin          = {IAS-5 / JSC / INM-9},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IAS-5-20120330 / I:(DE-Juel1)JSC-20090406 /
                      I:(DE-Juel1)INM-9-20140121},
      pnm          = {571 - Connectivity and Activity (POF3-571) / 574 - Theory,
                      modelling and simulation (POF3-574) / 511 - Computational
                      Science and Mathematical Methods (POF3-511)},
      pid          = {G:(DE-HGF)POF3-571 / G:(DE-HGF)POF3-574 /
                      G:(DE-HGF)POF3-511},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30577569},
      UT           = {WOS:000459747700018},
      doi          = {10.3390/ijms20010018},
      url          = {https://juser.fz-juelich.de/record/858742},
}