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100 1 _ |a Sánchez-López, Carolina
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245 _ _ |a Structural Determinants of the Prion Protein N-Terminus and Its Adducts with Copper Ions
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520 _ _ |a The N-terminus of the prion protein is a large intrinsically disordered region encompassing approximately 125 amino acids. In this paper, we review its structural and functional properties, with a particular emphasis on its binding to copper ions. The latter is exploited by the region’s conformational flexibility to yield a variety of biological functions. Disease-linked mutations and proteolytic processing of the protein can impact its copper-binding properties, with important structural and functional implications, both in health and disease progression.
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700 1 _ |a Rossetti, Giulia
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700 1 _ |a Quintanar, Liliana
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700 1 _ |a Carloni, Paolo
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773 _ _ |a 10.3390/ijms20010018
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