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@ARTICLE{Badhwar:858817,
author = {Badhwar, AmanPreet and Tam, Angela and Dansereau, Christian
and Orban, Pierre and Hoffstaedter, Felix and Bellec,
Pierre},
title = {{R}esting-state network dysfunction in {A}lzheimer's
disease: {A} systematic review and meta-analysis-},
journal = {Alzheimer's $\&$ dementia / Diagnosis, assessment $\&$
disease monitoring Diagnosis, assessment $\&$ disease
monitoring [...]},
volume = {8},
issn = {2352-8729},
address = {Amsterdam [u.a.]},
publisher = {Elsevier},
reportid = {FZJ-2018-07657},
pages = {73 - 85},
year = {2017},
note = {The computational resources used to perform the
dataanalysis were provided by Compute Canada
(www.computecanada.org) and CLUMEQ (www.clumeq.mcgill.ca),
which is funded in part by NSERC (MRS), FQRNT,and McGill
University.This research was supported by the Canadian
Consortiumon Neurodegeneration in Aging. The Canadian
Consortiumon Neurodegeneration in Aging is supported bya
grant from the Canadian Institutes of Health Researchwith
funding from several partners including the AlzheimerSociety
of Canada, Sanofi, and Women’s BrainHealth Initiative.
This research was also supported bythe Courtois Foundation
(P.B.) and an Alzheimer SocietyPostdoctoral Fellowship
(A.B.).},
abstract = {Introduction: We performed a systematic review and
meta-analysis of the Alzheimer’s disease (AD)literature to
examine consistency of functional connectivity alterations
in AD dementia and mildcognitive impairment, using
resting-state functional magnetic resonance imaging.Methods:
Studies were screened using a standardized procedure.
Multiresolution statistics wereperformed to assess the
spatial consistency of findings across studies.Results:
Thirty-four studies were included (1363 participants,
average 40 per study). Consistentalterations in connectivity
were found in the default mode, salience, and limbic
networks in patientswith AD dementia, mild cognitive
impairment, or in both groups.We also identified a strong
tendencyin the literature toward specific examination of the
default mode network.Discussion: Convergent evidence across
the literature supports the use of resting-state
connectivityas a biomarker of AD. The locations of
consistent alterations suggest that highly connected
hubregions in the brain might be an early target of AD. 2017
The Authors. Published by Elsevier Inc. on behalf of the
Alzheimer’s Association. This is anopen access article
under the CC BY-NC-ND license
(http://creativecommons.org/licenses/by-nc-nd/4.0/).Keywords:
Resting-state fMRI; Functional connectivity; Alzheimer’s
disease; Mild cognitive impairment; Meta-analysis1.
IntroductionAlzheimer’s disease (AD) exists on a
continuumcomprising a},
cin = {INM-7},
ddc = {610},
cid = {I:(DE-Juel1)INM-7-20090406},
pnm = {572 - (Dys-)function and Plasticity (POF3-572)},
pid = {G:(DE-HGF)POF3-572},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:28560308},
doi = {10.1016/j.dadm.2017.03.007},
url = {https://juser.fz-juelich.de/record/858817},
}