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000858910 1001_ $$0P:(DE-HGF)0$$aTaiwo, Bamigboye J.$$b0$$eCorresponding author
000858910 245__ $$aSchistosomiasis: Snail-vector control, molecular modelling and dynamic studies of bioactive N-acetylglycoside saponins from Tetrapleura tetraptera
000858910 260__ $$aOxford$$bElsevier Science$$c2018
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000858910 520__ $$aSchistosomiasis, a chronic neglected tropical disease caused by the Schistosoma spp. parasite, is associated with disabling patient symptoms. The new focus of the WHO roadmap on 'transmission control, wherever possible’ offers drug development opportunities for intermediate-host control to prevent human-to-snail-to-human parasite transmission. Reports on the analysis of the impact of ‘chemical-based mollusciciding’ have concluded that constant application of molluscicides may contribute significantly towards the elimination of schistosomiasis in endemic areas. In South-Western Nigeria, Tetrapleura tetraptera is a tree whose fruit has been widely used in snail vector control. The presence of molluscicidal N-acetyl triterpene glycosides in the fruit has been reported. In this study, a bioactivity-directed fractionation of the fruit extract was performed to isolate the most potent molluscicidal saponin from the fruit. In an attempt to provide mechanistic insight into the observed activity, in silico screening was performed, profiling the molluscicidal N-acetyl triterpene glycosides reported from the fruit against two potential therapeutic targets in the mollusk used, NADH-ubiquinone oxidoreductase (NAD1) and retinoid X receptor. The docking predicted binary complexes of the saponins, which were subjected to explicit solvent conformational sampling from which patterns of structural stability were obtained. The binding energies alone did not account for the potency of the saponins indicating the influence of other factor like pharmacokinetic parameters. The study concluded that there is a preferential suitability of ND1’s MWFE site for the rational design and development of novel molluscicidal agents.
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000858910 7001_ $$0P:(DE-HGF)0$$aOlubiyi, Olujide O.$$b1$$eCorresponding author
000858910 7001_ $$0P:(DE-Juel1)170073$$aWang, Xue$$b2$$ufzj
000858910 7001_ $$0P:(DE-HGF)0$$aFisusi, Funmilola A.$$b3
000858910 7001_ $$0P:(DE-HGF)0$$aAkinniyi, Ganiyu Akintayo$$b4
000858910 7001_ $$0P:(DE-HGF)0$$aVan Heerden, Fanie R.$$b5
000858910 7001_ $$0P:(DE-Juel1)132024$$aStrodel, Birgit$$b6$$ufzj
000858910 773__ $$0PERI:(DE-600)2110171-1$$a10.1016/j.compbiolchem.2018.09.011$$gVol. 77, p. 363 - 372$$p363 - 372$$tComputational biology and chemistry$$v77$$x1476-9271$$y2018
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