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000858912 1001_ $$00000-0002-2260-8493$$aLiao, Qinghua$$b0
000858912 245__ $$aAβ under stress: the effects of acidosis, Cu 2+ -binding, and oxidation on amyloid β-peptide dimers
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000858912 520__ $$aIn light of the high affinity of Cu2+ for Alzheimer's Aβ1–42 and its ability to subsequently catalyze the formation of radicals, we examine the effects of Cu2+ binding, Aβ oxidation, and an acidic environment on the conformational dynamics of the smallest Aβ1–42 oligomer, the Aβ1–42 dimer. Transition networks calculated from Hamiltonian replica exchange molecular dynamics (H-REMD) simulations reveal that the decreased pH considerably increased the β-sheet content, whereas Cu2+ binding increased the exposed hydrophobic surface area, both of which can contribute to an increased oligomerization propensity and toxicity.
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000858912 7001_ $$0P:(DE-HGF)0$$aOwen, Michael C.$$b1
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000858912 7001_ $$0P:(DE-Juel1)151182$$aBarz, Bogdan$$b3
000858912 7001_ $$0P:(DE-Juel1)132024$$aStrodel, Birgit$$b4$$eCorresponding author
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