% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Liao:858912,
      author       = {Liao, Qinghua and Owen, Michael C. and Bali, Sofia and
                      Barz, Bogdan and Strodel, Birgit},
      title        = {{A}β under stress: the effects of acidosis, {C}u 2+
                      -binding, and oxidation on amyloid β-peptide dimers},
      journal      = {Chemical communications},
      volume       = {54},
      number       = {56},
      issn         = {1364-548X},
      address      = {Cambridge},
      publisher    = {Soc.},
      reportid     = {FZJ-2018-07748},
      pages        = {7766 - 7769},
      year         = {2018},
      abstract     = {In light of the high affinity of Cu2+ for Alzheimer's
                      Aβ1–42 and its ability to subsequently catalyze the
                      formation of radicals, we examine the effects of Cu2+
                      binding, Aβ oxidation, and an acidic environment on the
                      conformational dynamics of the smallest Aβ1–42 oligomer,
                      the Aβ1–42 dimer. Transition networks calculated from
                      Hamiltonian replica exchange molecular dynamics (H-REMD)
                      simulations reveal that the decreased pH considerably
                      increased the β-sheet content, whereas Cu2+ binding
                      increased the exposed hydrophobic surface area, both of
                      which can contribute to an increased oligomerization
                      propensity and toxicity.},
      cin          = {ICS-6},
      ddc          = {540},
      cid          = {I:(DE-Juel1)ICS-6-20110106},
      pnm          = {551 - Functional Macromolecules and Complexes (POF3-551)},
      pid          = {G:(DE-HGF)POF3-551},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:29947363},
      UT           = {WOS:000438237700008},
      doi          = {10.1039/C8CC02263A},
      url          = {https://juser.fz-juelich.de/record/858912},
}