%0 Journal Article
%A Kalbe, Elke
%A Roheger, Mandy
%A Paluszak, Kay
%A Meyer, Julia
%A Becker, Jutta
%A Fink, Gereon R.
%A Kukolja, Juraj
%A Rahn, Andreas
%A Szabados, Florian
%A Wirth, Brunhilde
%A Kessler, Josef
%T Effects of a Cognitive Training With and Without Additional Physical Activity in Healthy Older Adults: A Follow-Up 1 Year After a Randomized Controlled Trial
%J Frontiers in aging neuroscience
%V 10
%@ 1663-4365
%C Lausanne
%I Frontiers Research Foundation
%M FZJ-2019-00006
%P 407
%D 2018
%X Background: Combining cognitive training (CT) with physical activity (CPT) has been suggested to be most effective in maintaining cognition in healthy older adults, but data are scarce and inconsistent regarding long-term effects (follow-up; FU) and predictors of success.Objective: To investigate the 1-year FU effects of CPT versus CT and CPT plus counseling (CPT+C), and to identify predictors for CPT success at FU.Setting and Participants: We included 55 healthy older participants in the data analyses; 18 participants (CPT group) were used for the predictor analysis.Interventions: In a randomized controlled trial, participants conducted a CT, CPT, or CPT+C for 7 weeks.Outcome Measures: Overall cognition, verbal, figural, and working memory, verbal fluency, attention, planning, and visuo-construction.Results: While within-group comparisons showed cognitive improvements for all types of training, only one significant interaction Group × Time favoring CPT in comparison to CPT+C was found for overall cognition and verbal long-term memory. The most consistent predictor for CPT success (in verbal short-term memory, verbal fluency, attention) was an initial low baseline performance. Lower education predicted working memory gains. Higher levels of insulin-like growth factor 1 (IGF-1) and lower levels of brain-derived neurotrophic factor at baseline (BDNF) predicted alternating letter verbal fluency gains.Discussion: Within-group comparisons indicate that all used training types are helpful to maintain cognition. The fact that cognitive and sociodemographic data as well as nerve growth factors predict long-term benefits of CPT contributes to the understanding of the mechanisms underlying training success and may ultimately help to adapt training to individual profiles
%F PUB:(DE-HGF)16
%9 Journal Article
%U <Go to ISI:>//WOS:000453665900001
%R 10.3389/fnagi.2018.00407
%U https://juser.fz-juelich.de/record/859036