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000859036 1001_ $$0P:(DE-HGF)0$$aKalbe, Elke$$b0$$eCorresponding author
000859036 245__ $$aEffects of a Cognitive Training With and Without Additional Physical Activity in Healthy Older Adults: A Follow-Up 1 Year After a Randomized Controlled Trial
000859036 260__ $$aLausanne$$bFrontiers Research Foundation$$c2018
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000859036 520__ $$aBackground: Combining cognitive training (CT) with physical activity (CPT) has been suggested to be most effective in maintaining cognition in healthy older adults, but data are scarce and inconsistent regarding long-term effects (follow-up; FU) and predictors of success.Objective: To investigate the 1-year FU effects of CPT versus CT and CPT plus counseling (CPT+C), and to identify predictors for CPT success at FU.Setting and Participants: We included 55 healthy older participants in the data analyses; 18 participants (CPT group) were used for the predictor analysis.Interventions: In a randomized controlled trial, participants conducted a CT, CPT, or CPT+C for 7 weeks.Outcome Measures: Overall cognition, verbal, figural, and working memory, verbal fluency, attention, planning, and visuo-construction.Results: While within-group comparisons showed cognitive improvements for all types of training, only one significant interaction Group × Time favoring CPT in comparison to CPT+C was found for overall cognition and verbal long-term memory. The most consistent predictor for CPT success (in verbal short-term memory, verbal fluency, attention) was an initial low baseline performance. Lower education predicted working memory gains. Higher levels of insulin-like growth factor 1 (IGF-1) and lower levels of brain-derived neurotrophic factor at baseline (BDNF) predicted alternating letter verbal fluency gains.Discussion: Within-group comparisons indicate that all used training types are helpful to maintain cognition. The fact that cognitive and sociodemographic data as well as nerve growth factors predict long-term benefits of CPT contributes to the understanding of the mechanisms underlying training success and may ultimately help to adapt training to individual profiles
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000859036 7001_ $$0P:(DE-HGF)0$$aMeyer, Julia$$b3
000859036 7001_ $$0P:(DE-HGF)0$$aBecker, Jutta$$b4
000859036 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b5
000859036 7001_ $$0P:(DE-Juel1)131730$$aKukolja, Juraj$$b6
000859036 7001_ $$0P:(DE-HGF)0$$aRahn, Andreas$$b7
000859036 7001_ $$0P:(DE-HGF)0$$aSzabados, Florian$$b8
000859036 7001_ $$0P:(DE-HGF)0$$aWirth, Brunhilde$$b9
000859036 7001_ $$0P:(DE-HGF)0$$aKessler, Josef$$b10
000859036 773__ $$0PERI:(DE-600)2558898-9$$a10.3389/fnagi.2018.00407$$gVol. 10, p. 407$$p407$$tFrontiers in aging neuroscience$$v10$$x1663-4365$$y2018
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