TY  - JOUR
AU  - Kalbe, Elke
AU  - Roheger, Mandy
AU  - Paluszak, Kay
AU  - Meyer, Julia
AU  - Becker, Jutta
AU  - Fink, Gereon R.
AU  - Kukolja, Juraj
AU  - Rahn, Andreas
AU  - Szabados, Florian
AU  - Wirth, Brunhilde
AU  - Kessler, Josef
TI  - Effects of a Cognitive Training With and Without Additional Physical Activity in Healthy Older Adults: A Follow-Up 1 Year After a Randomized Controlled Trial
JO  - Frontiers in aging neuroscience
VL  - 10
SN  - 1663-4365
CY  - Lausanne
PB  - Frontiers Research Foundation
M1  - FZJ-2019-00006
SP  - 407
PY  - 2018
AB  - Background: Combining cognitive training (CT) with physical activity (CPT) has been suggested to be most effective in maintaining cognition in healthy older adults, but data are scarce and inconsistent regarding long-term effects (follow-up; FU) and predictors of success.Objective: To investigate the 1-year FU effects of CPT versus CT and CPT plus counseling (CPT+C), and to identify predictors for CPT success at FU.Setting and Participants: We included 55 healthy older participants in the data analyses; 18 participants (CPT group) were used for the predictor analysis.Interventions: In a randomized controlled trial, participants conducted a CT, CPT, or CPT+C for 7 weeks.Outcome Measures: Overall cognition, verbal, figural, and working memory, verbal fluency, attention, planning, and visuo-construction.Results: While within-group comparisons showed cognitive improvements for all types of training, only one significant interaction Group × Time favoring CPT in comparison to CPT+C was found for overall cognition and verbal long-term memory. The most consistent predictor for CPT success (in verbal short-term memory, verbal fluency, attention) was an initial low baseline performance. Lower education predicted working memory gains. Higher levels of insulin-like growth factor 1 (IGF-1) and lower levels of brain-derived neurotrophic factor at baseline (BDNF) predicted alternating letter verbal fluency gains.Discussion: Within-group comparisons indicate that all used training types are helpful to maintain cognition. The fact that cognitive and sociodemographic data as well as nerve growth factors predict long-term benefits of CPT contributes to the understanding of the mechanisms underlying training success and may ultimately help to adapt training to individual profiles
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000453665900001
DO  - DOI:10.3389/fnagi.2018.00407
UR  - https://juser.fz-juelich.de/record/859036
ER  -