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| 001 | 859036 | ||
| 005 | 20210130000149.0 | ||
| 024 | 7 | _ | |a 10.3389/fnagi.2018.00407 |2 doi |
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| 100 | 1 | _ | |a Kalbe, Elke |0 P:(DE-HGF)0 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Effects of a Cognitive Training With and Without Additional Physical Activity in Healthy Older Adults: A Follow-Up 1 Year After a Randomized Controlled Trial |
| 260 | _ | _ | |a Lausanne |c 2018 |b Frontiers Research Foundation |
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| 520 | _ | _ | |a Background: Combining cognitive training (CT) with physical activity (CPT) has been suggested to be most effective in maintaining cognition in healthy older adults, but data are scarce and inconsistent regarding long-term effects (follow-up; FU) and predictors of success.Objective: To investigate the 1-year FU effects of CPT versus CT and CPT plus counseling (CPT+C), and to identify predictors for CPT success at FU.Setting and Participants: We included 55 healthy older participants in the data analyses; 18 participants (CPT group) were used for the predictor analysis.Interventions: In a randomized controlled trial, participants conducted a CT, CPT, or CPT+C for 7 weeks.Outcome Measures: Overall cognition, verbal, figural, and working memory, verbal fluency, attention, planning, and visuo-construction.Results: While within-group comparisons showed cognitive improvements for all types of training, only one significant interaction Group × Time favoring CPT in comparison to CPT+C was found for overall cognition and verbal long-term memory. The most consistent predictor for CPT success (in verbal short-term memory, verbal fluency, attention) was an initial low baseline performance. Lower education predicted working memory gains. Higher levels of insulin-like growth factor 1 (IGF-1) and lower levels of brain-derived neurotrophic factor at baseline (BDNF) predicted alternating letter verbal fluency gains.Discussion: Within-group comparisons indicate that all used training types are helpful to maintain cognition. The fact that cognitive and sociodemographic data as well as nerve growth factors predict long-term benefits of CPT contributes to the understanding of the mechanisms underlying training success and may ultimately help to adapt training to individual profiles |
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| 773 | _ | _ | |a 10.3389/fnagi.2018.00407 |g Vol. 10, p. 407 |0 PERI:(DE-600)2558898-9 |p 407 |t Frontiers in aging neuroscience |v 10 |y 2018 |x 1663-4365 |
| 856 | 4 | _ | |y OpenAccess |u https://juser.fz-juelich.de/record/859036/files/Kalbe_2018_Frontiers%20in%20Aging%20Neuroscience_Effects%20of%20a%20cognitive%20training%20with%20and%20without%20additional%20physical%20activity.pdf |
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