% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Menzel:859132,
      author       = {Menzel, Miriam and Axer, Markus and Amunts, Katrin and De
                      Raedt, Hans and Michielsen, Kristel},
      title        = {{D}iattenuation {I}maging reveals different brain tissue
                      properties},
      journal      = {Scientific reports},
      volume       = {9},
      number       = {1},
      issn         = {2045-2322},
      address      = {[London]},
      publisher    = {Macmillan Publishers Limited, part of Springer Nature},
      reportid     = {FZJ-2019-00068},
      pages        = {1939},
      year         = {2019},
      abstract     = {When transmitting polarised light through histological
                      brain sections, different types of diattenuation
                      (polarisation-dependent attenuation of light) can be
                      observed: In some brain regions, the light is minimally
                      attenuated when it is polarised parallel to the nerve fibres
                      (referred to as D+), in others, it is maximally attenuated
                      (referred to as D-). The underlying mechanisms of these
                      effects and their relationship to tissue properties were so
                      far unknown. Here, we demonstrate in experimental studies
                      that diattenuation of both types D+ and D- can be observed
                      in brain tissue samples from different species (rodent,
                      monkey, and human) and that the strength and type of
                      diattenuation depend on the nerve fibre orientations. By
                      combining finite-difference time-domain simulations and
                      analytical modelling, we explain the observed diattenuation
                      effects and show that they are caused both by anisotropic
                      absorption (dichroism) and by anisotropic light scattering.
                      Our studies demonstrate that the diattenuation signal
                      depends not only on the nerve fibre orientations but also on
                      other brain tissue properties like tissue homogeneity, fibre
                      size, and myelin sheath thickness. This allows to use the
                      diattenuation signal to distinguish between brain regions
                      with different tissue properties and establishes
                      Diattenuation Imaging as a valuable imaging technique.},
      cin          = {INM-1 / JSC / JARA-HPC},
      ddc          = {600},
      cid          = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)JSC-20090406 /
                      $I:(DE-82)080012_20140620$},
      pnm          = {574 - Theory, modelling and simulation (POF3-574) / 511 -
                      Computational Science and Mathematical Methods (POF3-511) /
                      SMHB - Supercomputing and Modelling for the Human Brain
                      (HGF-SMHB-2013-2017) / HBP SGA1 - Human Brain Project
                      Specific Grant Agreement 1 (720270) / SIMULATIONS FOR THE
                      RECONSTRUCTION OF NERVE FIBERS BY 3D POLARIZED LIGHT IMAGING
                      $(jjsc24_20150501)$ / HBP SGA2 - Human Brain Project
                      Specific Grant Agreement 2 (785907) / Simulations for a
                      better Understanding of the Impact of Different Brain Tissue
                      Components on 3D Polarized Light Imaging
                      $(jjsc43_20181101)$},
      pid          = {G:(DE-HGF)POF3-574 / G:(DE-HGF)POF3-511 /
                      G:(DE-Juel1)HGF-SMHB-2013-2017 / G:(EU-Grant)720270 /
                      $G:(DE-Juel1)jjsc24_20150501$ / G:(EU-Grant)785907 /
                      $G:(DE-Juel1)jjsc43_20181101$},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30760789},
      doi          = {10.1038/s41598-019-38506-w},
      url          = {https://juser.fz-juelich.de/record/859132},
}