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000859138 1001_ $$0P:(DE-HGF)0$$aNaumova, Natalia$$b0
000859138 245__ $$aMicrowave characterization of low-molecular-weight antioxidant specific biomarkers
000859138 260__ $$aAmsterdam [u.a.]$$bElsevier$$c2019
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000859138 520__ $$aAntioxidants play a crucial role in the life sciences, as the regulators of biochemical reactions. We studied the dielectric properties of the low-molecular weight antioxidant specific biomarkers sodium ascorbate and glutathione in solutions of different concentrations. The biomarkers are multifunctional metabolites relevant to the reactive oxygen species (ROS) scavenging system of cells. The newly developed high-Q microwave whispering-gallery-mode (WGM) dielectric resonator based technique was applied. The technique allows investigation of liquids of nanoliter volumes filled in microfluidic channel within several milliseconds. The revealed peculiarities in the dependence of permittivity on concentrations of the sodium ascorbate and glutathione solutions are explained by differences in relaxation times and loses introduced by molecules of different shapes. We suggest that this novel approach offers the potential for the detection and characterization of ROS-relevant biomarkers with millisecond-time resolution.
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000859138 7001_ $$0P:(DE-Juel1)164250$$aHlukhova, Hanna$$b1$$ufzj
000859138 7001_ $$0P:(DE-HGF)0$$aBarannik, Alexander$$b2
000859138 7001_ $$0P:(DE-HGF)0$$aGubin, Alexey$$b3
000859138 7001_ $$0P:(DE-HGF)0$$aProtsenko, Irina$$b4
000859138 7001_ $$0P:(DE-HGF)0$$aCherpak, Nickolay$$b5
000859138 7001_ $$0P:(DE-Juel1)128738$$aVitusevich, Svetlana$$b6$$eCorresponding author
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