TY  - JOUR
AU  - Schwacke, Rainer
AU  - Ponce-Soto, Gabriel Y.
AU  - Krause, Kirsten
AU  - Bolger, Anthony M.
AU  - Arsova, Borjana
AU  - Hallab, Asis
AU  - Gruden, Kristina
AU  - Stitt, Mark
AU  - Bolger, Marie
AU  - Usadel, Björn
TI  - MapMan4: a refined protein classification and annotation framework applicable to multi-omics data analysis
JO  - Molecular plant
VL  - 12
IS  - 6
SN  - 1674-2052
CY  - Oxford
PB  - Oxford Univ. Press
M1  - FZJ-2019-00093
SP  - 879-892
PY  - 2019
AB  - Genome sequences from over 200 plant species have already been published, with this number expected to increase rapidly due to advances in sequencing technologies. Once a new genome has been assembled and the genes identified, the functional annotation of their proteins using ontologies is of key importance as it places the sequencing data in a biological context. Furthermore, in order to keep pace with rapid production of genome sequences, this functional annotation process must be fully automated.Here we present a redesigned and significantly enhanced MapMan4 framework, together with a revised version of the associated online Mercator annotation tool. Compared to the original MapMan, the new ontology has been expanded almost threefold and now enforces stricter assignment rules. This ontology has been incorporated into Mercator4, which has been upgraded to reflect current knowledge across the land plant group and thus provides protein annotations for all embryophytes with a comparably high quality. The annotation process has been optimized to allow a plant genome to be annotated in a matter of minutes. The output results continue to be compatible with the established MapMan desktop application.
LB  - PUB:(DE-HGF)16
C6  - pmid:30639314
UR  - <Go to ISI:>//WOS:000469954400011
DO  - DOI:10.1016/j.molp.2019.01.003
UR  - https://juser.fz-juelich.de/record/859203
ER  -