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@ARTICLE{Dong:859354,
      author       = {Dong, Y. and Teleman, A. A. and Jedmowski, C. and Wirtz, M.
                      and Hell, R.},
      title        = {{T}he {A}rabidopsis {THADA} homologue modulates {TOR}
                      activity and cold acclimation},
      journal      = {Plant biology},
      volume       = {21},
      number       = {S1},
      issn         = {1438-8677},
      address      = {Oxford [u.a.]},
      publisher    = {Wiley- Blackwell},
      reportid     = {FZJ-2019-00222},
      pages        = {77 - 83},
      year         = {2019},
      abstract     = {Low temperature is one of the most important environmental
                      factors that affect global survival of humans and animals
                      and equally importantly the distribution of plants and crop
                      productivity. Survival of metazoan cells under cold stress
                      requires regulation of the sensor‐kinase Target Of
                      Rapamycin (TOR). TOR controls growth of eukaryotic cells by
                      adjusting anabolic and catabolic metabolism. Previous
                      studies identified the Thyroid Adenoma Associated (THADA)
                      gene as the major effect locus by positive selection in the
                      evolution of modern human adapted to cold. Here we
                      investigate the role of THADA in TOR signaling and cold
                      acclimation of plants. We applied BLAST searches and
                      homology modeling to identify the AtTHADA (AT3G55160) in
                      Arabidopsis thaliana as the highly probable orthologue
                      protein. Reverse genetics approaches were combined with
                      immunological detection of TOR activity and metabolite
                      profiling to address the role of the TOR and THADA for
                      growth regulation and cold acclimation. Depletion of the
                      AtTHADA gene caused complete or partial loss of
                      full‐length mRNA, respectively, and significant
                      retardation of growth under non‐stressed conditions.
                      Furthermore, depletion of AtTHADA caused hypersensitivity
                      towards low‐temperatures. Atthada displayed a lowered
                      energy charge. This went along with decreased TOR activity,
                      which offers a molecular explanation for the slow growth
                      phenotype of Atthada. Finally, we used TOR RNAi lines to
                      identify the de‐regulation of TOR activity as one
                      determinant for sensitivity towards low‐temperatures.
                      Taken together our results provide evidence for a conserved
                      function of THADA in cold acclimation of eukaryotes and
                      suggest that cold acclimation in plants requires regulation
                      of TOR.},
      cin          = {IBG-2},
      ddc          = {580},
      cid          = {I:(DE-Juel1)IBG-2-20101118},
      pnm          = {582 - Plant Science (POF3-582) / DPPN - Deutsches Pflanzen
                      Phänotypisierungsnetzwerk (BMBF-031A053A)},
      pid          = {G:(DE-HGF)POF3-582 / G:(DE-Juel1)BMBF-031A053A},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30098100},
      UT           = {WOS:000455045100009},
      doi          = {10.1111/plb.12893},
      url          = {https://juser.fz-juelich.de/record/859354},
}