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| Home > Publications database > Diattenuation Imaging reveals different brain tissue properties > print |
| 001 | 859428 | ||
| 005 | 20210130000254.0 | ||
| 024 | 7 | _ | |a arXiv:1806.07712 |2 arXiv |
| 024 | 7 | _ | |a 2128/21190 |2 Handle |
| 024 | 7 | _ | |a altmetric:43939043 |2 altmetric |
| 037 | _ | _ | |a FZJ-2019-00286 |
| 082 | _ | _ | |a 910 |
| 100 | 1 | _ | |a Menzel, Miriam |0 P:(DE-Juel1)161196 |b 0 |e Corresponding author |u fzj |
| 245 | _ | _ | |a Diattenuation Imaging reveals different brain tissue properties |
| 260 | _ | _ | |c 2018 |
| 336 | 7 | _ | |a Preprint |b preprint |m preprint |0 PUB:(DE-HGF)25 |s 1553172073_30752 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a WORKING_PAPER |2 ORCID |
| 336 | 7 | _ | |a Electronic Article |0 28 |2 EndNote |
| 336 | 7 | _ | |a preprint |2 DRIVER |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
| 336 | 7 | _ | |a Output Types/Working Paper |2 DataCite |
| 500 | _ | _ | |a 18 pages, 9 figures arXiv:1806.07712v4 |
| 520 | _ | _ | |a When transmitting polarised light through histological brain sections, different types of diattenuation (polarisation-dependent attenuation of light) can be observed: In some brain regions, the light is minimally attenuated when it is polarised parallel to the nerve fibres (referred to as D+), in others, it is maximally attenuated (referred to as D-). The underlying mechanisms of these effects and their relationship to tissue properties were so far unknown. Here, we demonstrate in experimental studies that diattenuation of both types D+ and D- can be observed in brain tissue samples from different species (rodent, monkey, and human) and that the strength and type of diattenuation depend on the nerve fibre orientations. By combining finite-difference time-domain simulations and analytical modelling, we explain the observed diattenuation effects and show that they are caused both by anisotropic absorption (dichroism) and by anisotropic light scattering. Our studies demonstrate that the diattenuation signal depends not only on the nerve fibre orientations but also on other brain tissue properties like tissue homogeneity, fibre size, and myelin sheath thickness. This allows to use the diattenuation signal to distinguish between brain regions with different tissue properties and establishes Diattenuation Imaging as a valuable imaging technique. |
| 536 | _ | _ | |a 571 - Connectivity and Activity (POF3-571) |0 G:(DE-HGF)POF3-571 |c POF3-571 |f POF III |x 0 |
| 536 | _ | _ | |a 574 - Theory, modelling and simulation (POF3-574) |0 G:(DE-HGF)POF3-574 |c POF3-574 |f POF III |x 1 |
| 536 | _ | _ | |a 511 - Computational Science and Mathematical Methods (POF3-511) |0 G:(DE-HGF)POF3-511 |c POF3-511 |f POF III |x 2 |
| 536 | _ | _ | |a SMHB - Supercomputing and Modelling for the Human Brain (HGF-SMHB-2013-2017) |0 G:(DE-Juel1)HGF-SMHB-2013-2017 |c HGF-SMHB-2013-2017 |f SMHB |x 3 |
| 536 | _ | _ | |a HBP SGA1 - Human Brain Project Specific Grant Agreement 1 (720270) |0 G:(EU-Grant)720270 |c 720270 |f H2020-Adhoc-2014-20 |x 4 |
| 536 | _ | _ | |a HBP SGA2 - Human Brain Project Specific Grant Agreement 2 (785907) |0 G:(EU-Grant)785907 |c 785907 |f H2020-SGA-FETFLAG-HBP-2017 |x 5 |
| 588 | _ | _ | |a Dataset connected to arXivarXiv |
| 700 | 1 | _ | |a Axer, Markus |0 P:(DE-Juel1)131632 |b 1 |u fzj |
| 700 | 1 | _ | |a Amunts, Katrin |0 P:(DE-Juel1)131631 |b 2 |u fzj |
| 700 | 1 | _ | |a De Raedt, Hans |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Michielsen, Kristel |0 P:(DE-Juel1)138295 |b 4 |u fzj |
| 773 | _ | _ | |y 2019 |0 PERI:(DE-600)2465034-1 |x 0068-1261 |
| 856 | 4 | _ | |u https://arxiv.org/abs/1806.07712 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/859428/files/arXiv_1806.07712_v4.pdf |y OpenAccess |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/859428/files/arXiv_1806.07712_v4.pdf?subformat=pdfa |x pdfa |y OpenAccess |
| 909 | C | O | |o oai:juser.fz-juelich.de:859428 |p openaire |p open_access |p driver |p VDB |p ec_fundedresources |p dnbdelivery |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 0 |6 P:(DE-Juel1)161196 |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 1 |6 P:(DE-Juel1)131632 |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 2 |6 P:(DE-Juel1)131631 |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 4 |6 P:(DE-Juel1)138295 |
| 913 | 1 | _ | |a DE-HGF |b Key Technologies |l Decoding the Human Brain |1 G:(DE-HGF)POF3-570 |0 G:(DE-HGF)POF3-571 |2 G:(DE-HGF)POF3-500 |v Connectivity and Activity |x 0 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |
| 913 | 1 | _ | |a DE-HGF |b Key Technologies |l Decoding the Human Brain |1 G:(DE-HGF)POF3-570 |0 G:(DE-HGF)POF3-574 |2 G:(DE-HGF)POF3-500 |v Theory, modelling and simulation |x 1 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |
| 913 | 1 | _ | |a DE-HGF |b Key Technologies |1 G:(DE-HGF)POF3-510 |0 G:(DE-HGF)POF3-511 |2 G:(DE-HGF)POF3-500 |v Computational Science and Mathematical Methods |x 2 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |l Supercomputing & Big Data |
| 914 | 1 | _ | |y 2018 |
| 915 | _ | _ | |a OpenAccess |0 StatID:(DE-HGF)0510 |2 StatID |
| 920 | _ | _ | |l yes |
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| 980 | _ | _ | |a preprint |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-Juel1)INM-1-20090406 |
| 980 | _ | _ | |a I:(DE-Juel1)JSC-20090406 |
| 980 | _ | _ | |a UNRESTRICTED |
| 980 | 1 | _ | |a FullTexts |
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