TY  - JOUR
AU  - Moussa, Mariam
AU  - Ebrahim, Weaam
AU  - Bonus, Michele
AU  - Gohlke, Holger
AU  - Mándi, Attila
AU  - Kurtán, Tibor
AU  - Hartmann, Rudolf
AU  - Kalscheuer, Rainer
AU  - Lin, Wenhan
AU  - Liu, Zhen
AU  - Proksch, Peter
TI  - Co-culture of the fungus Fusarium tricinctum with Streptomyces lividans induces production of cryptic naphthoquinone dimers
JO  - RSC Advances
VL  - 9
IS  - 3
SN  - 2046-2069
CY  - London
PB  - RSC Publishing
M1  - FZJ-2019-00292
SP  - 1491 - 1500
PY  - 2019
AB  - Co-cultivation of the endophytic fungus Fusarium tricinctum with Streptomyces lividans on solid rice medium led to the production of four new naphthoquinone dimers, fusatricinones A–D (1–4), and a new lateropyrone derivative, dihydrolateropyrone (5), that were not detected in axenic fungal controls. In addition, four known cryptic compounds, zearalenone (7), (−)-citreoisocoumarin (8), macrocarpon C (9) and 7-hydroxy-2-(2-hydroxypropyl)-5-methylchromone (10), that were likewise undetectable in extracts from fungal controls, were obtained from the co-culture extracts. The known antibiotically active compound lateropyrone (6), the depsipeptides enniatins B (11), B1 (12) and A1 (13), and the lipopeptide fusaristatin A (14), that were present in axenic fungal controls and in co-culture extracts, were upregulated in the latter. The structures of the new compounds were elucidated by 1D and 2D NMR spectra as well as by HRESIMS data. The relative and absolute configuration of dihydrolateropyrone (5) was elucidated by TDDFT-ECD calculations.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000457292800036
DO  - DOI:10.1039/C8RA09067J
UR  - https://juser.fz-juelich.de/record/859436
ER  -