TY  - JOUR
AU  - Plachti, Anna
AU  - Eickhoff, Simon
AU  - Hoffstaedter, Felix
AU  - Patil, Kaustubh
AU  - Laird, Angela R
AU  - Fox, Peter T
AU  - Amunts, Katrin
AU  - Genon, Sarah
TI  - Multimodal Parcellations and Extensive Behavioral Profiling Tackling the Hippocampus Gradient
JO  - Cerebral cortex
VL  - 29
IS  - 11
SN  - 1460-2199
CY  - Oxford
PB  - Oxford Univ. Press
M1  - FZJ-2019-01290
SP  - 4595-4612
PY  - 2019
N1  - Deutsche Forschungsgemeinschaft (DFG, GE 2835/1-1, EI 816/4-1),the National Institute of Mental Health (R01-MH074457), theHelmholtz Portfolio Theme “Supercomputing and Modelling forthe Human Brain,” and the European Union’s Horizon 2020Research and Innovation Programme under Grant Agreement No.720270 (HBP SGA1) and No. 785907 (HBP SGA2).Open Access Gebühren ergänzt 19.09.19
AB  - The hippocampus displays a complex organization and function that is perturbed in many neuropathologies. Histological work revealed a complex arrangement of subfields along the medial–lateral and the ventral–dorsal dimension, which contrasts with the anterior–posterior functional differentiation. The variety of maps has raised the need for an integrative multimodal view. We applied connectivity-based parcellation to 1) intrinsic connectivity 2) task-based connectivity, and 3) structural covariance, as complementary windows into structural and functional differentiation of the hippocampus. Strikingly, while functional properties (i.e., intrinsic and task-based) revealed similar partitions dominated by an anterior–posterior organization, structural covariance exhibited a hybrid pattern reflecting both functional and cytoarchitectonic subdivision. Capitalizing on the consistency of functional parcellations, we defined robust functional maps at different levels of partitions, which are openly available for the scientific community. Our functional maps demonstrated a head–body and tail partition, subdivided along the anterior–posterior and medial–lateral axis. Behavioral profiling of these fine partitions based on activation data indicated an emotion–cognition gradient along the anterior–posterior axis and additionally suggested a self-world-centric gradient supporting the role of the hippocampus in the construction of abstract representations for spatial navigation and episodic memory.
LB  - PUB:(DE-HGF)16
C6  - pmid:30721944
UR  - <Go to ISI:>//WOS:000506813700010
DO  - DOI:10.1093/cercor/bhy336
UR  - https://juser.fz-juelich.de/record/860614
ER  -