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@ARTICLE{Plachti:860614,
author = {Plachti, Anna and Eickhoff, Simon and Hoffstaedter, Felix
and Patil, Kaustubh and Laird, Angela R and Fox, Peter T and
Amunts, Katrin and Genon, Sarah},
title = {{M}ultimodal {P}arcellations and {E}xtensive {B}ehavioral
{P}rofiling {T}ackling the {H}ippocampus {G}radient},
journal = {Cerebral cortex},
volume = {29},
number = {11},
issn = {1460-2199},
address = {Oxford},
publisher = {Oxford Univ. Press},
reportid = {FZJ-2019-01290},
pages = {4595-4612},
year = {2019},
note = {Deutsche Forschungsgemeinschaft (DFG, GE 2835/1-1, EI
816/4-1),the National Institute of Mental Health
(R01-MH074457), theHelmholtz Portfolio Theme
“Supercomputing and Modelling forthe Human Brain,” and
the European Union’s Horizon 2020Research and Innovation
Programme under Grant Agreement No.720270 (HBP SGA1) and No.
785907 (HBP SGA2).Open Access Gebühren ergänzt 19.09.19},
abstract = {The hippocampus displays a complex organization and
function that is perturbed in many neuropathologies.
Histological work revealed a complex arrangement of
subfields along the medial–lateral and the
ventral–dorsal dimension, which contrasts with the
anterior–posterior functional differentiation. The variety
of maps has raised the need for an integrative multimodal
view. We applied connectivity-based parcellation to 1)
intrinsic connectivity 2) task-based connectivity, and 3)
structural covariance, as complementary windows into
structural and functional differentiation of the
hippocampus. Strikingly, while functional properties (i.e.,
intrinsic and task-based) revealed similar partitions
dominated by an anterior–posterior organization,
structural covariance exhibited a hybrid pattern reflecting
both functional and cytoarchitectonic subdivision.
Capitalizing on the consistency of functional parcellations,
we defined robust functional maps at different levels of
partitions, which are openly available for the scientific
community. Our functional maps demonstrated a head–body
and tail partition, subdivided along the
anterior–posterior and medial–lateral axis. Behavioral
profiling of these fine partitions based on activation data
indicated an emotion–cognition gradient along the
anterior–posterior axis and additionally suggested a
self-world-centric gradient supporting the role of the
hippocampus in the construction of abstract representations
for spatial navigation and episodic memory.},
cin = {INM-1 / INM-7},
ddc = {610},
cid = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)INM-7-20090406},
pnm = {571 - Connectivity and Activity (POF3-571) / SMHB -
Supercomputing and Modelling for the Human Brain
(HGF-SMHB-2013-2017) / HBP SGA1 - Human Brain Project
Specific Grant Agreement 1 (720270) / HBP SGA2 - Human Brain
Project Specific Grant Agreement 2 (785907)},
pid = {G:(DE-HGF)POF3-571 / G:(DE-Juel1)HGF-SMHB-2013-2017 /
G:(EU-Grant)720270 / G:(EU-Grant)785907},
typ = {PUB:(DE-HGF)16},
pubmed = {pmid:30721944},
UT = {WOS:000506813700010},
doi = {10.1093/cercor/bhy336},
url = {https://juser.fz-juelich.de/record/860614},
}