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@ARTICLE{Bittner:860654,
      author       = {Bittner, Nora and Jockwitz, Christiane and Mühleisen,
                      Thomas W. and Hoffstaedter, Felix and Eickhoff, Simon and
                      Moebus, Susanne and Bayen, Ute J. and Cichon, Sven and
                      Zilles, Karl and Amunts, Katrin and Caspers, Svenja},
      title        = {{C}ombining lifestyle risks to disentangle brain structure
                      and functional connectivity differences in older adults},
      journal      = {Nature Communications},
      volume       = {10},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {FZJ-2019-01322},
      pages        = {621},
      year         = {2019},
      note         = {This project was partially funded by the German National
                      Cohort and the 1000BRAINSstudy of the Institute of
                      Neuroscience and Medicine, Research Center Juelich,
                      Germany.We thank the Heinz Nixdorf Foundation (Germany) for
                      the generous support of theHeinz Nixdorf Study. We also
                      thank the scientists and the study staff of the HeinzNixdorf
                      Recall Study and 1000BRAINS. The study is also supported by
                      the GermanMinistry of Education and Science. The authors are
                      supported by the Initiative andNetworking Fund of the
                      Helmholtz Association (S.Ca.) and the European
                      Union’sHorizon 2020 Research and Innovation Program under
                      Grant Agreement 720270(Human Brain Project SGA1; K.A., K.Z.,
                      S.Ca., S.Ci.) and 785907 (Human Brain ProjectSGA2; K.A.,
                      K.Z., S.Ca., S.Ci.). This work was further supported by the
                      German FederalMinistry of Education and Research (BMBF)
                      through the Integrated Network Integra-Ment (Integrated
                      Understanding of Causes and Mechanisms in Mental Disorders)
                      underthe auspices of the e:Med Program (grant 01ZX1314A to
                      S.Ci.), and by},
      abstract     = {Lifestyle contributes to inter-individual variability in
                      brain aging, but previous studies focusedon the effects of
                      single lifestyle variables. Here, we studied the combined
                      and individualcontributions of four lifestyle variables -
                      alcohol consumption, smoking, physical activity,and social
                      integration - to brain structure and functional connectivity
                      in a population-basedcohort of 549 older adults. A combined
                      lifestyle risk score was associated with
                      decreasedgyrification in left premotor and right prefrontal
                      cortex, and higher functional connectivityto sensorimotor
                      and prefrontal cortex. While structural differences were
                      driven by alcoholconsumption, physical activity, and social
                      integration, higher functional connectivity wasdriven by
                      smoking. Results suggest that combining differentially
                      contributing lifestylevariables may be more than the sum of
                      its parts. Associations generally were neither alteredby
                      adjustment for genetic risk, nor by depressive
                      symptomatology or education, underliningthe relevance of
                      daily habits for brain health.},
      cin          = {INM-1 / INM-7},
      ddc          = {500},
      cid          = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)INM-7-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571) / HBP SGA1 -
                      Human Brain Project Specific Grant Agreement 1 (720270) /
                      HBP SGA2 - Human Brain Project Specific Grant Agreement 2
                      (785907)},
      pid          = {G:(DE-HGF)POF3-571 / G:(EU-Grant)720270 /
                      G:(EU-Grant)785907},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30728360},
      UT           = {WOS:000457862200006},
      doi          = {10.1038/s41467-019-08500-x},
      url          = {https://juser.fz-juelich.de/record/860654},
}