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024 7 _ |a 10.1038/s41467-019-08500-x
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100 1 _ |a Bittner, Nora
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245 _ _ |a Combining lifestyle risks to disentangle brain structure and functional connectivity differences in older adults
260 _ _ |a [London]
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500 _ _ |a This project was partially funded by the German National Cohort and the 1000BRAINSstudy of the Institute of Neuroscience and Medicine, Research Center Juelich, Germany.We thank the Heinz Nixdorf Foundation (Germany) for the generous support of theHeinz Nixdorf Study. We also thank the scientists and the study staff of the HeinzNixdorf Recall Study and 1000BRAINS. The study is also supported by the GermanMinistry of Education and Science. The authors are supported by the Initiative andNetworking Fund of the Helmholtz Association (S.Ca.) and the European Union’sHorizon 2020 Research and Innovation Program under Grant Agreement 720270(Human Brain Project SGA1; K.A., K.Z., S.Ca., S.Ci.) and 785907 (Human Brain ProjectSGA2; K.A., K.Z., S.Ca., S.Ci.). This work was further supported by the German FederalMinistry of Education and Research (BMBF) through the Integrated Network Integra-Ment (Integrated Understanding of Causes and Mechanisms in Mental Disorders) underthe auspices of the e:Med Program (grant 01ZX1314A to S.Ci.), and by
520 _ _ |a Lifestyle contributes to inter-individual variability in brain aging, but previous studies focusedon the effects of single lifestyle variables. Here, we studied the combined and individualcontributions of four lifestyle variables - alcohol consumption, smoking, physical activity,and social integration - to brain structure and functional connectivity in a population-basedcohort of 549 older adults. A combined lifestyle risk score was associated with decreasedgyrification in left premotor and right prefrontal cortex, and higher functional connectivityto sensorimotor and prefrontal cortex. While structural differences were driven by alcoholconsumption, physical activity, and social integration, higher functional connectivity wasdriven by smoking. Results suggest that combining differentially contributing lifestylevariables may be more than the sum of its parts. Associations generally were neither alteredby adjustment for genetic risk, nor by depressive symptomatology or education, underliningthe relevance of daily habits for brain health.
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700 1 _ |a Jockwitz, Christiane
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700 1 _ |a Mühleisen, Thomas W.
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700 1 _ |a Hoffstaedter, Felix
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700 1 _ |a Eickhoff, Simon
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700 1 _ |a Moebus, Susanne
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700 1 _ |a Bayen, Ute J.
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700 1 _ |a Cichon, Sven
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700 1 _ |a Zilles, Karl
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700 1 _ |a Amunts, Katrin
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700 1 _ |a Caspers, Svenja
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773 _ _ |a 10.1038/s41467-019-08500-x
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