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@INPROCEEDINGS{Schrader:860657,
author = {Schrader, Tobias Erich},
title = {{N}eutron protein crystallography at the
{H}einz{M}aier-{L}eibnitz {Z}entrum ({MLZ}): {I}s there
anythingto offer beyond neutrons?},
reportid = {FZJ-2019-01325},
year = {2018},
abstract = {This contribution will first give an in depth introduction
into the instrument BIODIFF at MLZ. It will show the current
status and planned upgrades. Further upgrades and new sample
environment options such as a humidity gas stream should
also be discussed for the instrument BIODIFF. This gas
stream would offer a humidity range between 30 $\%$ and
$99.8\%$ relative humidity. Here, two main applications can
be identified: A) Controlled hydration and de-hydration of
the crystal to improve crystal quality and therefore the
achievable resolution. B) Contrast variation with precise
mixtures of heavy and light water in the gas stream to
change the contrast of lipids with respect to protein in the
protein crystal. Furthermore, this gas stream will enable
measurements at room temperature without the need of a
capillary around the crystal. This will reduce the
background due to incoherent scattering from the glas walls
of the capillary.Running a beam line one inevitably gets
some overview on the needs of users. But this overview maybe
limited to the actions performed on site. Therefore, I
intend to ask the audience of this workshop for feedback for
improvements to make on the instrument and surrounding
facilities (laboratories etc.).Looking into the far future,
I also see potential of offering help upstream (data
interpretation, data visualization) and downstream (support
in large crystal growth) of the value chain in producing a
neutron protein crystallography publication. An interesting
feature would be to use virtual reality goggles in order to
view the neutron or x-ray structure in 3-D. With one's own
hands one can navigate and crawl along the protein backbone
to find the active center. This would give a more intuitive
approach to the understanding of the catalytic mechanism of
a protein, especially when one can switch between two
structures in the catalytic process by just pressing a
button in one's hand.},
month = {Aug},
date = {2018-08-21},
organization = {European Crystallography meeting -
Satellite Workshop: Neutron
macromolecular crystallography for
structural chemistry and biology
studies that are at an impasse with
other techniques, Oviedo (Spain), 21
Aug 2018 - 22 Aug 2018},
subtyp = {Invited},
cin = {JCNS-FRM-II / Neutronenstreuung ; JCNS-1},
cid = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
I:(DE-Juel1)JCNS-1-20110106},
pnm = {6G15 - FRM II / MLZ (POF3-6G15) / 6215 - Soft Matter,
Health and Life Sciences (POF3-621) / 6G4 - Jülich Centre
for Neutron Research (JCNS) (POF3-623)},
pid = {G:(DE-HGF)POF3-6G15 / G:(DE-HGF)POF3-6215 /
G:(DE-HGF)POF3-6G4},
experiment = {EXP:(DE-MLZ)BIODIFF-20140101},
typ = {PUB:(DE-HGF)6},
url = {https://juser.fz-juelich.de/record/860657},
}