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@INPROCEEDINGS{Schrader:860657,
      author       = {Schrader, Tobias Erich},
      title        = {{N}eutron protein crystallography at the
                      {H}einz{M}aier-{L}eibnitz {Z}entrum ({MLZ}): {I}s there
                      anythingto offer beyond neutrons?},
      reportid     = {FZJ-2019-01325},
      year         = {2018},
      abstract     = {This contribution will first give an in depth introduction
                      into the instrument BIODIFF at MLZ. It will show the current
                      status and planned upgrades. Further upgrades and new sample
                      environment options such as a humidity gas stream should
                      also be discussed for the instrument BIODIFF. This gas
                      stream would offer a humidity range between 30 $\%$ and
                      $99.8\%$ relative humidity. Here, two main applications can
                      be identified: A) Controlled hydration and de-hydration of
                      the crystal to improve crystal quality and therefore the
                      achievable resolution. B) Contrast variation with precise
                      mixtures of heavy and light water in the gas stream to
                      change the contrast of lipids with respect to protein in the
                      protein crystal. Furthermore, this gas stream will enable
                      measurements at room temperature without the need of a
                      capillary around the crystal. This will reduce the
                      background due to incoherent scattering from the glas walls
                      of the capillary.Running a beam line one inevitably gets
                      some overview on the needs of users. But this overview maybe
                      limited to the actions performed on site. Therefore, I
                      intend to ask the audience of this workshop for feedback for
                      improvements to make on the instrument and surrounding
                      facilities (laboratories etc.).Looking into the far future,
                      I also see potential of offering help upstream (data
                      interpretation, data visualization) and downstream (support
                      in large crystal growth) of the value chain in producing a
                      neutron protein crystallography publication. An interesting
                      feature would be to use virtual reality goggles in order to
                      view the neutron or x-ray structure in 3-D. With one's own
                      hands one can navigate and crawl along the protein backbone
                      to find the active center. This would give a more intuitive
                      approach to the understanding of the catalytic mechanism of
                      a protein, especially when one can switch between two
                      structures in the catalytic process by just pressing a
                      button in one's hand.},
      month         = {Aug},
      date          = {2018-08-21},
      organization  = {European Crystallography meeting -
                       Satellite Workshop: Neutron
                       macromolecular crystallography for
                       structural chemistry and biology
                       studies that are at an impasse with
                       other techniques, Oviedo (Spain), 21
                       Aug 2018 - 22 Aug 2018},
      subtyp        = {Invited},
      cin          = {JCNS-FRM-II / Neutronenstreuung ; JCNS-1},
      cid          = {I:(DE-Juel1)JCNS-FRM-II-20110218 /
                      I:(DE-Juel1)JCNS-1-20110106},
      pnm          = {6G15 - FRM II / MLZ (POF3-6G15) / 6215 - Soft Matter,
                      Health and Life Sciences (POF3-621) / 6G4 - Jülich Centre
                      for Neutron Research (JCNS) (POF3-623)},
      pid          = {G:(DE-HGF)POF3-6G15 / G:(DE-HGF)POF3-6215 /
                      G:(DE-HGF)POF3-6G4},
      experiment   = {EXP:(DE-MLZ)BIODIFF-20140101},
      typ          = {PUB:(DE-HGF)6},
      url          = {https://juser.fz-juelich.de/record/860657},
}