Gast ::
| Hauptseite > Publikationsdatenbank > Neutron protein crystallography at the HeinzMaier-Leibnitz Zentrum (MLZ): Is there anythingto offer beyond neutrons? > print |
| Hauptseite > Publikationsdatenbank > Neutron protein crystallography at the HeinzMaier-Leibnitz Zentrum (MLZ): Is there anythingto offer beyond neutrons? > print |
| 001 | 860657 | ||
| 005 | 20210130000552.0 | ||
| 037 | _ | _ | |a FZJ-2019-01325 |
| 100 | 1 | _ | |a Schrader, Tobias Erich |0 P:(DE-Juel1)138266 |b 0 |e Corresponding author |u fzj |
| 111 | 2 | _ | |a European Crystallography meeting - Satellite Workshop: Neutron macromolecular crystallography for structural chemistry and biology studies that are at an impasse with other techniques |c Oviedo |d 2018-08-21 - 2018-08-22 |w Spain |
| 245 | _ | _ | |a Neutron protein crystallography at the HeinzMaier-Leibnitz Zentrum (MLZ): Is there anythingto offer beyond neutrons? |
| 260 | _ | _ | |c 2018 |
| 336 | 7 | _ | |a Conference Paper |0 33 |2 EndNote |
| 336 | 7 | _ | |a Other |2 DataCite |
| 336 | 7 | _ | |a INPROCEEDINGS |2 BibTeX |
| 336 | 7 | _ | |a conferenceObject |2 DRIVER |
| 336 | 7 | _ | |a LECTURE_SPEECH |2 ORCID |
| 336 | 7 | _ | |a Conference Presentation |b conf |m conf |0 PUB:(DE-HGF)6 |s 1550065228_14779 |2 PUB:(DE-HGF) |x Invited |
| 520 | _ | _ | |a This contribution will first give an in depth introduction into the instrument BIODIFF at MLZ. It will show the current status and planned upgrades. Further upgrades and new sample environment options such as a humidity gas stream should also be discussed for the instrument BIODIFF. This gas stream would offer a humidity range between 30 % and 99.8% relative humidity. Here, two main applications can be identified: A) Controlled hydration and de-hydration of the crystal to improve crystal quality and therefore the achievable resolution. B) Contrast variation with precise mixtures of heavy and light water in the gas stream to change the contrast of lipids with respect to protein in the protein crystal. Furthermore, this gas stream will enable measurements at room temperature without the need of a capillary around the crystal. This will reduce the background due to incoherent scattering from the glas walls of the capillary.Running a beam line one inevitably gets some overview on the needs of users. But this overview maybe limited to the actions performed on site. Therefore, I intend to ask the audience of this workshop for feedback for improvements to make on the instrument and surrounding facilities (laboratories etc.).Looking into the far future, I also see potential of offering help upstream (data interpretation, data visualization) and downstream (support in large crystal growth) of the value chain in producing a neutron protein crystallography publication. An interesting feature would be to use virtual reality goggles in order to view the neutron or x-ray structure in 3-D. With one's own hands one can navigate and crawl along the protein backbone to find the active center. This would give a more intuitive approach to the understanding of the catalytic mechanism of a protein, especially when one can switch between two structures in the catalytic process by just pressing a button in one's hand. |
| 536 | _ | _ | |0 G:(DE-HGF)POF3-6G15 |f POF III |x 0 |c POF3-6G15 |a 6G15 - FRM II / MLZ (POF3-6G15) |
| 536 | _ | _ | |a 6215 - Soft Matter, Health and Life Sciences (POF3-621) |0 G:(DE-HGF)POF3-6215 |c POF3-621 |f POF III |x 1 |
| 536 | _ | _ | |a 6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623) |0 G:(DE-HGF)POF3-6G4 |c POF3-623 |f POF III |x 2 |
| 650 | 1 | 7 | |a Health and Life |0 V:(DE-MLZ)GC-130-2016 |2 V:(DE-HGF) |x 0 |
| 650 | 2 | 7 | |a Biology |0 V:(DE-MLZ)SciArea-160 |2 V:(DE-HGF) |x 0 |
| 693 | _ | _ | |a Forschungs-Neutronenquelle Heinz Maier-Leibnitz |e BIODIFF: Diffractometer for large unit cells |f NL1 |1 EXP:(DE-MLZ)FRMII-20140101 |0 EXP:(DE-MLZ)BIODIFF-20140101 |5 EXP:(DE-MLZ)BIODIFF-20140101 |6 EXP:(DE-MLZ)NL1-20140101 |x 0 |
| 909 | C | O | |o oai:juser.fz-juelich.de:860657 |p VDB:MLZ |p VDB |
| 910 | 1 | _ | |a Forschungszentrum Jülich |0 I:(DE-588b)5008462-8 |k FZJ |b 0 |6 P:(DE-Juel1)138266 |
| 913 | 1 | _ | |a DE-HGF |9 G:(DE-HGF)POF3-6G15 |x 0 |4 G:(DE-HGF)POF |v FRM II / MLZ |1 G:(DE-HGF)POF3-6G0 |0 G:(DE-HGF)POF3-6G15 |3 G:(DE-HGF)POF3 |2 G:(DE-HGF)POF3-600 |b Forschungsbereich Materie |l Großgeräte: Materie |
| 913 | 1 | _ | |a DE-HGF |b Forschungsbereich Materie |l Von Materie zu Materialien und Leben |1 G:(DE-HGF)POF3-620 |0 G:(DE-HGF)POF3-621 |2 G:(DE-HGF)POF3-600 |v In-house research on the structure, dynamics and function of matter |9 G:(DE-HGF)POF3-6215 |x 1 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |
| 913 | 1 | _ | |a DE-HGF |b Forschungsbereich Materie |l Von Materie zu Materialien und Leben |1 G:(DE-HGF)POF3-620 |0 G:(DE-HGF)POF3-623 |2 G:(DE-HGF)POF3-600 |v Facility topic: Neutrons for Research on Condensed Matter |9 G:(DE-HGF)POF3-6G4 |x 2 |4 G:(DE-HGF)POF |3 G:(DE-HGF)POF3 |
| 914 | 1 | _ | |y 2019 |
| 920 | _ | _ | |l yes |
| 920 | 1 | _ | |0 I:(DE-Juel1)JCNS-FRM-II-20110218 |k JCNS-FRM-II |l JCNS-FRM-II |x 0 |
| 920 | 1 | _ | |0 I:(DE-Juel1)JCNS-1-20110106 |k Neutronenstreuung ; JCNS-1 |l Neutronenstreuung |x 1 |
| 980 | _ | _ | |a conf |
| 980 | _ | _ | |a VDB |
| 980 | _ | _ | |a I:(DE-Juel1)JCNS-FRM-II-20110218 |
| 980 | _ | _ | |a I:(DE-Juel1)JCNS-1-20110106 |
| 980 | _ | _ | |a UNRESTRICTED |
| Library | Collection | CLSMajor | CLSMinor | Language | Author |
|---|