000860695 001__ 860695
000860695 005__ 20210130000600.0
000860695 0247_ $$2doi$$a10.1111/gbb.12550
000860695 0247_ $$2ISSN$$a1601-183X
000860695 0247_ $$2ISSN$$a1601-1848
000860695 0247_ $$2pmid$$apmid:30585408
000860695 0247_ $$2WOS$$aWOS:000458365000007
000860695 0247_ $$2altmetric$$aaltmetric:53198909
000860695 037__ $$aFZJ-2019-01360
000860695 082__ $$a610
000860695 1001_ $$00000-0001-8081-9275$$aGünther, Anne$$b0$$eCorresponding author
000860695 245__ $$aHCN4 knockdown in dorsal hippocampus promotes anxiety-like behavior in mice
000860695 260__ $$a[S.l.]$$bWiley-Blackwell$$c2019
000860695 3367_ $$2DRIVER$$aarticle
000860695 3367_ $$2DataCite$$aOutput Types/Journal article
000860695 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1549973445_26323
000860695 3367_ $$2BibTeX$$aARTICLE
000860695 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000860695 3367_ $$00$$2EndNote$$aJournal Article
000860695 520__ $$aHyperpolarization‐activated and cyclic nucleotide‐gated (HCN) channels mediate the Ih current in the murine hippocampus. Disruption of the Ih current by knockout of HCN1, HCN2 or tetratricopeptide repeat‐containing Rab8b‐interacting protein has been shown to affect physiological processes such as synaptic integration and maintenance of resting membrane potentials as well as several behaviors in mice, including depressive‐like and anxiety‐like behaviors. However, the potential involvement of the HCN4 isoform in these processes is unknown. Here, we assessed the contribution of the HCN4 isoform to neuronal processing and hippocampus‐based behaviors in mice. We show that HCN4 is expressed in various regions of the hippocampus, with distinct expression patterns that partially overlapped with other HCN isoforms. For behavioral analysis, we specifically modulated HCN4 expression by injecting recombinant adeno‐associated viral (rAAV) vectors mediating expression of short hairpin RNA against hcn4 (shHcn4) into the dorsal hippocampus of mice. HCN4 knockdown produced no effect on contextual fear conditioning or spatial memory. However, a pronounced anxiogenic effect was evident in mice treated with shHcn4 compared to control littermates. Our findings suggest that HCN4 specifically contributes to anxiety‐like behaviors in mice.
000860695 536__ $$0G:(DE-HGF)POF3-552$$a552 - Engineering Cell Function (POF3-552)$$cPOF3-552$$fPOF III$$x0
000860695 588__ $$aDataset connected to CrossRef
000860695 7001_ $$00000-0001-8747-9429$$aLuczak, Vincent$$b1
000860695 7001_ $$0P:(DE-Juel1)145762$$aGruteser, Nadine$$b2
000860695 7001_ $$00000-0003-2423-4592$$aAbel, Ted$$b3
000860695 7001_ $$0P:(DE-Juel1)131911$$aBaumann, Arnd$$b4
000860695 773__ $$0PERI:(DE-600)2061212-6$$a10.1111/gbb.12550$$gVol. 18, no. 2, p. e12550 -$$n2$$pe12550 -$$tGenes, brain and behavior$$v18$$x1601-1848$$y2019
000860695 8564_ $$uhttps://juser.fz-juelich.de/record/860695/files/gbb.12550.pdf$$yRestricted
000860695 8564_ $$uhttps://juser.fz-juelich.de/record/860695/files/gbb.12550.pdf?subformat=pdfa$$xpdfa$$yRestricted
000860695 909CO $$ooai:juser.fz-juelich.de:860695$$pVDB
000860695 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131911$$aForschungszentrum Jülich$$b4$$kFZJ
000860695 9131_ $$0G:(DE-HGF)POF3-552$$1G:(DE-HGF)POF3-550$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lBioSoft – Fundamentals for future Technologies in the fields of Soft Matter and Life Sciences$$vEngineering Cell Function$$x0
000860695 9141_ $$y2019
000860695 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bGENES BRAIN BEHAV : 2017
000860695 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000860695 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000860695 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000860695 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000860695 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000860695 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000860695 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000860695 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000860695 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000860695 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000860695 920__ $$lyes
000860695 9201_ $$0I:(DE-Juel1)ICS-4-20110106$$kICS-4$$lZelluläre Biophysik$$x0
000860695 980__ $$ajournal
000860695 980__ $$aVDB
000860695 980__ $$aI:(DE-Juel1)ICS-4-20110106
000860695 980__ $$aUNRESTRICTED
000860695 981__ $$aI:(DE-Juel1)IBI-1-20200312