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@ARTICLE{Gnther:860695,
      author       = {Günther, Anne and Luczak, Vincent and Gruteser, Nadine and
                      Abel, Ted and Baumann, Arnd},
      title        = {{HCN}4 knockdown in dorsal hippocampus promotes
                      anxiety-like behavior in mice},
      journal      = {Genes, brain and behavior},
      volume       = {18},
      number       = {2},
      issn         = {1601-1848},
      address      = {[S.l.]},
      publisher    = {Wiley-Blackwell},
      reportid     = {FZJ-2019-01360},
      pages        = {e12550 -},
      year         = {2019},
      abstract     = {Hyperpolarization‐activated and cyclic nucleotide‐gated
                      (HCN) channels mediate the Ih current in the murine
                      hippocampus. Disruption of the Ih current by knockout of
                      HCN1, HCN2 or tetratricopeptide repeat‐containing
                      Rab8b‐interacting protein has been shown to affect
                      physiological processes such as synaptic integration and
                      maintenance of resting membrane potentials as well as
                      several behaviors in mice, including depressive‐like and
                      anxiety‐like behaviors. However, the potential involvement
                      of the HCN4 isoform in these processes is unknown. Here, we
                      assessed the contribution of the HCN4 isoform to neuronal
                      processing and hippocampus‐based behaviors in mice. We
                      show that HCN4 is expressed in various regions of the
                      hippocampus, with distinct expression patterns that
                      partially overlapped with other HCN isoforms. For behavioral
                      analysis, we specifically modulated HCN4 expression by
                      injecting recombinant adeno‐associated viral (rAAV)
                      vectors mediating expression of short hairpin RNA against
                      hcn4 (shHcn4) into the dorsal hippocampus of mice. HCN4
                      knockdown produced no effect on contextual fear conditioning
                      or spatial memory. However, a pronounced anxiogenic effect
                      was evident in mice treated with shHcn4 compared to control
                      littermates. Our findings suggest that HCN4 specifically
                      contributes to anxiety‐like behaviors in mice.},
      cin          = {ICS-4},
      ddc          = {610},
      cid          = {I:(DE-Juel1)ICS-4-20110106},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30585408},
      UT           = {WOS:000458365000007},
      doi          = {10.1111/gbb.12550},
      url          = {https://juser.fz-juelich.de/record/860695},
}