TY  - JOUR
AU  - Werner, Jan-Michael
AU  - Schweinsberg, Viola
AU  - Schroeter, Michael
AU  - von Reutern, Boris
AU  - Malter, Michael P.
AU  - Schlaak, Max
AU  - Fink, Gereon R.
AU  - Mauch, Cornelia
AU  - Galldiks, Norbert
TI  - Successful Treatment of Myasthenia Gravis Following PD-1/CTLA-4 Combination Checkpoint Blockade in a Patient With Metastatic Melanoma
JO  - Frontiers in oncology
VL  - 9
SN  - 2234-943X
CY  - Lausanne
PB  - Frontiers Media
M1  - FZJ-2019-01479
SP  - 84
PY  - 2019
AB  - Currently, the blockade of certain immune checkpoints such as the cytotoxic T-lymphocyte-associated protein 4 (CTLA-4) and programmed cell death-1 (PD-1) using checkpoint inhibitors is standard of care in patients with metastatic melanoma, especially with BRAF wild-type. However, several checkpoint inhibitor-related complications have been reported, including severe adverse events in the central and peripheral nervous system. In particular, in the recent past, the occurrence of myasthenia gravis following checkpoint inhibitor monotherapy, particularly nivolumab or ipilimumab, has been reported. In contrast, reports on PD-1/CTLA-4 combination blockade—usually with fatal clinical outcome—are scarce. We here report a case with combination immune checkpoint blockade-related myasthenia gravis with favorable clinical outcome.
LB  - PUB:(DE-HGF)16
UR  - <Go to ISI:>//WOS:000458677200001
DO  - DOI:10.3389/fonc.2019.00084
UR  - https://juser.fz-juelich.de/record/860824
ER  -