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@ARTICLE{Schneider:860836,
      author       = {Schneider, Christian and Sprenger, Alina and Weiss, Kilian
                      and Slebocki, Karin and Maintz, David and Fink, Gereon R.
                      and Henning, Tobias D. and Lehmann, Helmar C. and
                      Lichtenstein, Thorsten},
      title        = {{MRI} detects peripheral nerve and adjacent muscle
                      pathology in non-systemic vasculitic neuropathy ({NSVN})},
      journal      = {Journal of neurology},
      volume       = {266},
      number       = {4},
      issn         = {0340-5354},
      address      = {Berlin},
      publisher    = {Springer85301},
      reportid     = {FZJ-2019-01491},
      pages        = {975-981},
      year         = {2019},
      abstract     = {BackgroundDiagnosis and disease monitoring of non-systemic
                      vasculitic neuropathy (NSVN) are based on
                      electrophysiological and clinical measures. However, these
                      methods are insensitive to detect subtle differences of
                      axonal injury. We here assessed the utility of a
                      multiparametric MRI protocol to quantify axonal injury and
                      neurogenic muscle damage in NSVN.MethodsTen NSVN patients
                      and ten age-matched controls were investigated in this
                      single-center prospective study. All participants were
                      assessed by diffusion tensor imaging (DTI) of the tibial
                      nerve and multiecho Dixon MRI of soleus and gastrocnemius
                      muscles. These data were correlated with clinical and
                      electrophysiological data.ResultsDTI scans of the tibial
                      nerves of patients with NSVN showed significantly lower mean
                      fractional anisotropy (FA) values (0.32 ± 0.02)
                      compared to healthy controls (0.42 ± 0.01). FA values
                      of NSVN patients correlated negatively with clinical
                      measures of pain. Multiecho Dixon MRI scans revealed
                      significantly higher intramuscular fat fractions in the
                      soleus muscle $(19.86 ± 6.18\%$ vs.
                      $5.86 ± 0.74\%,$ p = 0.0015) and gastrocnemius
                      muscle $(26.09 ± 6.21\%$ vs. $3.59 ± 0.82\%,$
                      p = 0.0002) in NSVN patients compared to healthy
                      controls.ConclusionOur data provide a proof of concept that
                      MRI can render information about nerve integrity and muscle
                      pathology in NSVN. Further studies are warranted to evaluate
                      DTI and multiecho Dixon MRI as surrogate markers in NSVN.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30762104},
      UT           = {WOS:000463969200020},
      doi          = {10.1007/s00415-019-09224-0},
      url          = {https://juser.fz-juelich.de/record/860836},
}