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@ARTICLE{Schuepbach:860977,
      author       = {Schuepbach, W. M. Michael and Tonder, Lisa and Schnitzler,
                      Alfons and Krack, Paul and Rau, Joern and Hartmann, Andreas
                      and Hälbig, Thomas and Pineau, Fanny and Falk, Andrea and
                      Paschen, Laura and Paschen, Stephen and Volkmann, Jens and
                      Dafsari, Haidar S. and Barbe, Michael and Fink, Gereon R.
                      and Kühn, Andrea and Kupsch, Andreas and Schneider, Gerd-H.
                      and Seigneuret, Eric and Fraix, Valerie and Kistner, Andrea
                      and Chaynes, P. Patrick and Ory-Magne, Fabienne and
                      Brefel-Courbon, Christine and Vesper, Jan and Wojtecki, Lars
                      and Derrey, Stéphane and Maltête, David and Damier,
                      Philippe and Derkinderen, Pascal and Sixel-Döring,
                      Friederike and Trenkwalder, Claudia and Gharabaghi, Alireza
                      and Wächter, Tobias and Weiss, Daniel and Pinsker, Marcus
                      O. and Regis, Jean-Marie and Witjas, Tatiana and Thobois,
                      Stephane and Mertens, Patrick and Knudsen, Karina and
                      Schade-Brittinger, Carmen and Houeto, Jean-Luc and Agid,
                      Yves and Vidailhet, Marie and Timmermann, Lars and Deuschl,
                      Günther},
      title        = {{Q}uality of life predicts outcome of deep brain
                      stimulation in early {P}arkinson disease},
      journal      = {Neurology},
      volume       = {92},
      number       = {10},
      issn         = {1526-632X},
      address      = {[S.l.]},
      publisher    = {Ovid},
      reportid     = {FZJ-2019-01610},
      pages        = {e1109},
      year         = {2019},
      abstract     = {Objective To investigate predictors for improvement of
                      disease-specific quality of life (QOL) after deep brain
                      stimulation (DBS) of the subthalamic nucleus (STN) for
                      Parkinson disease (PD) with early motor
                      complications.Methods We performed a secondary analysis of
                      data from the previously published EARLYSTIM study, a
                      prospective randomized trial comparing STN-DBS (n = 124) to
                      best medical treatment (n = 127) after 2 years follow-up
                      with disease-specific QOL (39-item Parkinson's Disease
                      Questionnaire summary index [PDQ-39-SI]) as the primary
                      endpoint. Linear regression analyses of the baseline
                      characteristics age, disease duration, duration of motor
                      complications, and disease severity measured at baseline
                      with the Unified Parkinson’s Disease Rating Scale (UPDRS)
                      (UPDRS-III “off” and “on” medications, UPDRS-IV)
                      were conducted to determine predictors of change in
                      PDQ-39-SI.Results PDQ-39-SI at baseline was correlated to
                      the change in PDQ-39-SI after 24 months in both treatment
                      groups (p < 0.05). The higher the baseline score (worse QOL)
                      the larger the improvement in QOL after 24 months. No
                      correlation was found for any of the other baseline
                      characteristics analyzed in either treatment
                      group.Conclusion Impaired QOL as subjectively evaluated by
                      the patient is the most important predictor of benefit in
                      patients with PD and early motor complications, fulfilling
                      objective gold standard inclusion criteria for STN-DBS. Our
                      results prompt systematically including evaluation of
                      disease-specific QOL when selecting patients with PD for
                      STN-DBS.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30737338},
      UT           = {WOS:000463252900018},
      doi          = {10.1212/WNL.0000000000007037},
      url          = {https://juser.fz-juelich.de/record/860977},
}