% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Geisler:860986,
      author       = {Geisler, Stefanie and Stegmayr, Carina and Niemietz, Nicole
                      and Lohmann, Philipp and Rapp, Marion and Stoffels, Gabriele
                      and Willuweit, Antje and Galldiks, Norbert and Filss,
                      Christian and Sabel, Michael and Coenen, Heinrich Hubert and
                      Shah, N. J. and Langen, Karl-Josef},
      title        = {{T}reatment-related uptake of {O}-(2-[ 18
                      {F}]fluoroethyl)-{L}-tyrosine and {L}-[methyl- 3
                      {H}]-methionine after tumor resection in rat glioma model},
      journal      = {Journal of nuclear medicine},
      volume       = {60},
      number       = {10},
      issn         = {0161-5505},
      address      = {Reston, Va.},
      publisher    = {SNM},
      reportid     = {FZJ-2019-01616},
      pages        = {1373-1379},
      year         = {2019},
      abstract     = {Assessment of residual tumor after resection of cerebral
                      gliomas can be difficult with MRI and may be improved by
                      amino acid PET. The aim of this experimental study was to
                      investigate uptake of (2-[18F]fluoroethyl)-L-tyrosine
                      (18F-FET) and L-[methyl-3H]-methionine (3H-MET) in residual
                      tumor after surgery and possible false positive uptake in
                      treatment-related changes. Methods: F98 or GS-9L rat gliomas
                      were implanted into the brain of 64 rats. Tumors were
                      resected after one week of tumor growth and sham surgery was
                      performed in additional 10 animals. At different time points
                      after surgery (1, 2, 3, 7, 14-16 days), rats underwent ex
                      vivo dual tracer autoradiography using 18F-FET and 3H-MET.
                      Histological slices were evaluated by immunostainings for
                      cell density and astrogliosis. Tracer uptake was determined
                      by regions of interest and quantified by lesion-to-brain
                      ratios (L/B). Four animals underwent PET to examine time
                      activity curves of 18F-FET uptake. Results:
                      Treatment-related uptake with a mean L/B of 2.0 ± 0.3 for
                      18F-FET and a mean L/B of 1.7 ± 0.2 for 3H-MET was noted at
                      the rim of the resection cavity in the first week after
                      surgery which decreased significantly by 14-16 days (P <
                      0.01). Treatment-related tracer uptake was significantly
                      higher for 18F-FET than for 3H-MET (P < 0.001). Reactive
                      astrogliosis was noted in the vicinity of the resection
                      cavity from the second day after surgery. Time-activity
                      curves of 18F-FET uptake in those areas revealed constantly
                      increasing uptake. Conclusion: Surgery may induce
                      significant treatment-related 18F-FET and 3H-MET uptake in
                      the vicinity of the resection cavity in the first week after
                      surgery presumably caused by reactive astrogliosis.
                      Assessment of residual tumor after surgery by amino acid PET
                      seems to be more reliable after an interval of 14 days.},
      cin          = {INM-4 / JARA-BRAIN / INM-5 / INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / $I:(DE-82)080010_20140620$ /
                      I:(DE-Juel1)INM-5-20090406 / I:(DE-Juel1)INM-3-20090406},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30850492},
      UT           = {WOS:000488537100016},
      doi          = {10.2967/jnumed.119.225680},
      url          = {https://juser.fz-juelich.de/record/860986},
}