%0 Journal Article
%A Königschulte, W.
%A Civai, C.
%A Hildebrand, P.
%A Gaber, T. J.
%A Fink, G. R.
%A Zepf, F. D.
%T Effects of serotonin depletion and dopamine depletion on bimodal divided attention
%J The world journal of biological psychiatry
%V 21
%N 3
%@ 1562-2975
%C Abingdon
%I Taylor & Francis Group
%M FZJ-2019-01701
%P 183 - 194
%D 2020
%X This study aimed to explore the effects of acute phenylalanine tyrosine depletion (APTD) and acute tryptophan depletion (ATD) on bimodal divided attention. A balanced amino acid mixture (BAL) served as control condition.Fifty-three healthy adults (final analyzed sample was N = 49, age: M = 23.8 years) were randomly assigned to APTD, ATD or BAL in a double-blind, between-subject approach. Divided attention was assessed after 4 h. Blood samples were taken before and 6 h after challenge intake.Amino acid concentrations following challenge intake significantly decreased (all P ≤ 0.01). There was a significant difference in the mean reaction time (RT) towards auditory stimuli, but not towards visual stimuli between the groups. Post-hoc comparison of mean RTs (auditory stimuli) showed a significant difference between ATD (RT = 604.0 ms, SD = 56.9 ms) and APTD (RT = 556.4 ms, SD = 54.2 ms; P = 0.037), but no RT difference between ATD and BAL or APTD and BAL (RT = 573.6 ms, SD = 45.7 ms).The results indicate a possible dissociation between the effects of a diminished brain 5-HT and DA synthesis on the performance in a bimodal divided attention task. The difference was exclusively observed within the RT towards auditory signals.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:30295116
%U <Go to ISI:>//WOS:000533695800004
%R 10.1080/15622975.2018.1532110
%U https://juser.fz-juelich.de/record/861144