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000861144 1001_ $$0P:(DE-HGF)0$$aKönigschulte, W.$$b0
000861144 245__ $$aEffects of serotonin depletion and dopamine depletion on bimodal divided attention
000861144 260__ $$aAbingdon$$bTaylor & Francis Group$$c2020
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000861144 520__ $$aThis study aimed to explore the effects of acute phenylalanine tyrosine depletion (APTD) and acute tryptophan depletion (ATD) on bimodal divided attention. A balanced amino acid mixture (BAL) served as control condition.Fifty-three healthy adults (final analyzed sample was N = 49, age: M = 23.8 years) were randomly assigned to APTD, ATD or BAL in a double-blind, between-subject approach. Divided attention was assessed after 4 h. Blood samples were taken before and 6 h after challenge intake.Amino acid concentrations following challenge intake significantly decreased (all P ≤ 0.01). There was a significant difference in the mean reaction time (RT) towards auditory stimuli, but not towards visual stimuli between the groups. Post-hoc comparison of mean RTs (auditory stimuli) showed a significant difference between ATD (RT = 604.0 ms, SD = 56.9 ms) and APTD (RT = 556.4 ms, SD = 54.2 ms; P = 0.037), but no RT difference between ATD and BAL or APTD and BAL (RT = 573.6 ms, SD = 45.7 ms).The results indicate a possible dissociation between the effects of a diminished brain 5-HT and DA synthesis on the performance in a bimodal divided attention task. The difference was exclusively observed within the RT towards auditory signals.
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000861144 7001_ $$0P:(DE-HGF)0$$aCivai, C.$$b1
000861144 7001_ $$0P:(DE-HGF)0$$aHildebrand, P.$$b2
000861144 7001_ $$0P:(DE-HGF)0$$aGaber, T. J.$$b3
000861144 7001_ $$0P:(DE-Juel1)131720$$aFink, G. R.$$b4
000861144 7001_ $$0P:(DE-HGF)0$$aZepf, F. D.$$b5$$eCorresponding author
000861144 773__ $$0PERI:(DE-600)2170223-8$$a10.1080/15622975.2018.1532110$$gp. 1 - 12$$n3$$p183 - 194$$tThe world journal of biological psychiatry$$v21$$x1562-2975$$y2020
000861144 8564_ $$uhttps://juser.fz-juelich.de/record/861144/files/Koenigschulte_etal_2018_WJBiolPsychiatry.pdf$$yPublished on 2019-01-04. Available in OpenAccess from 2020-01-04.
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