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@ARTICLE{Knigschulte:861144,
      author       = {Königschulte, W. and Civai, C. and Hildebrand, P. and
                      Gaber, T. J. and Fink, G. R. and Zepf, F. D.},
      title        = {{E}ffects of serotonin depletion and dopamine depletion on
                      bimodal divided attention},
      journal      = {The world journal of biological psychiatry},
      volume       = {21},
      number       = {3},
      issn         = {1562-2975},
      address      = {Abingdon},
      publisher    = {Taylor $\&$ Francis Group},
      reportid     = {FZJ-2019-01701},
      pages        = {183 - 194},
      year         = {2020},
      abstract     = {This study aimed to explore the effects of acute
                      phenylalanine tyrosine depletion (APTD) and acute tryptophan
                      depletion (ATD) on bimodal divided attention. A balanced
                      amino acid mixture (BAL) served as control
                      condition.Fifty-three healthy adults (final analyzed sample
                      was N = 49, age: M = 23.8 years) were randomly
                      assigned to APTD, ATD or BAL in a double-blind,
                      between-subject approach. Divided attention was assessed
                      after 4 h. Blood samples were taken before and 6 h after
                      challenge intake.Amino acid concentrations following
                      challenge intake significantly decreased (all
                      P ≤ 0.01). There was a significant difference in the
                      mean reaction time (RT) towards auditory stimuli, but not
                      towards visual stimuli between the groups. Post-hoc
                      comparison of mean RTs (auditory stimuli) showed a
                      significant difference between ATD (RT = 604.0 ms,
                      SD = 56.9 ms) and APTD (RT = 556.4 ms,
                      SD = 54.2 ms; P = 0.037), but no RT difference
                      between ATD and BAL or APTD and BAL (RT = 573.6 ms,
                      SD = 45.7 ms).The results indicate a possible
                      dissociation between the effects of a diminished brain 5-HT
                      and DA synthesis on the performance in a bimodal divided
                      attention task. The difference was exclusively observed
                      within the RT towards auditory signals.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30295116},
      UT           = {WOS:000533695800004},
      doi          = {10.1080/15622975.2018.1532110},
      url          = {https://juser.fz-juelich.de/record/861144},
}