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| 001 | 861144 | ||
| 005 | 20210130000727.0 | ||
| 024 | 7 | _ | |a 10.1080/15622975.2018.1532110 |2 doi |
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| 037 | _ | _ | |a FZJ-2019-01701 |
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| 100 | 1 | _ | |a Königschulte, W. |0 P:(DE-HGF)0 |b 0 |
| 245 | _ | _ | |a Effects of serotonin depletion and dopamine depletion on bimodal divided attention |
| 260 | _ | _ | |a Abingdon |c 2020 |b Taylor & Francis Group |
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| 520 | _ | _ | |a This study aimed to explore the effects of acute phenylalanine tyrosine depletion (APTD) and acute tryptophan depletion (ATD) on bimodal divided attention. A balanced amino acid mixture (BAL) served as control condition.Fifty-three healthy adults (final analyzed sample was N = 49, age: M = 23.8 years) were randomly assigned to APTD, ATD or BAL in a double-blind, between-subject approach. Divided attention was assessed after 4 h. Blood samples were taken before and 6 h after challenge intake.Amino acid concentrations following challenge intake significantly decreased (all P ≤ 0.01). There was a significant difference in the mean reaction time (RT) towards auditory stimuli, but not towards visual stimuli between the groups. Post-hoc comparison of mean RTs (auditory stimuli) showed a significant difference between ATD (RT = 604.0 ms, SD = 56.9 ms) and APTD (RT = 556.4 ms, SD = 54.2 ms; P = 0.037), but no RT difference between ATD and BAL or APTD and BAL (RT = 573.6 ms, SD = 45.7 ms).The results indicate a possible dissociation between the effects of a diminished brain 5-HT and DA synthesis on the performance in a bimodal divided attention task. The difference was exclusively observed within the RT towards auditory signals. |
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| 700 | 1 | _ | |a Zepf, F. D. |0 P:(DE-HGF)0 |b 5 |e Corresponding author |
| 773 | _ | _ | |a 10.1080/15622975.2018.1532110 |g p. 1 - 12 |0 PERI:(DE-600)2170223-8 |n 3 |p 183 - 194 |t The world journal of biological psychiatry |v 21 |y 2020 |x 1562-2975 |
| 856 | 4 | _ | |u https://juser.fz-juelich.de/record/861144/files/Koenigschulte_etal_2018_WJBiolPsychiatry.pdf |y Published on 2019-01-04. Available in OpenAccess from 2020-01-04. |
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