000861154 001__ 861154
000861154 005__ 20210130000729.0
000861154 0247_ $$2doi$$a10.1016/j.neuroimage.2019.02.033
000861154 0247_ $$2ISSN$$a1053-8119
000861154 0247_ $$2ISSN$$a1095-9572
000861154 0247_ $$2pmid$$apmid:30798010
000861154 0247_ $$2WOS$$aWOS:000462145700052
000861154 0247_ $$2altmetric$$aaltmetric:55900838
000861154 0247_ $$2Handle$$a2128/23186
000861154 037__ $$aFZJ-2019-01709
000861154 082__ $$a610
000861154 1001_ $$0P:(DE-Juel1)173070$$aKohl, Simon H.$$b0$$ufzj
000861154 245__ $$aReal-time fMRI neurofeedback training to improve eating behavior by self-regulation of the dorsolateral prefrontal cortex: A randomized controlled trial in overweight and obese subjects
000861154 260__ $$aOrlando, Fla.$$bAcademic Press$$c2019
000861154 3367_ $$2DRIVER$$aarticle
000861154 3367_ $$2DataCite$$aOutput Types/Journal article
000861154 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1552657394_21968
000861154 3367_ $$2BibTeX$$aARTICLE
000861154 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000861154 3367_ $$00$$2EndNote$$aJournal Article
000861154 520__ $$aObesity is associated with altered responses to food stimuli in prefrontal brain networks that mediate inhibitory control of ingestive behavior. In particular, activity of the dorsolateral prefrontal cortex (dlPFC) is reduced in obese compared to normal-weight subjects and has been linked to the success of weight-loss dietary interventions. In a randomized controlled trial in overweight/obese subjects, we investigated the effect on eating behavior of volitional up-regulation of dlPFC activity via real-time functional magnetic resonance imaging (fMRI) neurofeedback training.Thirty-eight overweight or obese subjects (BMI 25–40 kg/m2) took part in fMRI neurofeedback training with the aim of increasing activity of the left dlPFC (dlPFC group; n = 17) or of the visual cortex (VC/control group; n = 21). Participants were blinded to group assignment. The training session took place on a single day and included three training runs of six trials of up-regulation and passive viewing. Food appraisal and snack intake were assessed at screening, after training, and in a follow-up session four weeks later.Participants of both groups succeeded in up-regulating activity of the targeted brain area. However, participants of the control group also showed increased left dlPFC activity during up-regulation. Functional connectivity between dlPFC and ventromedial PFC, an area that processes food value, was generally increased during up-regulation compared to passive viewing. At follow-up compared to baseline, both groups rated pictures of high-, but not low-calorie foods as less palatable and chose them less frequently. Actual snack intake remained unchanged but palatability and choice ratings for chocolate cookies decreased after training.We demonstrate that one session of fMRI neurofeedback training enables individuals with increased body weight to up-regulate activity of the left dlPFC. Behavioral effects were observed in both groups, which might have been due to dlPFC co-activation in the control group and, in addition, unspecific training effects. Improved dlPFC-vmPFC functional connectivity furthermore suggested enhanced food intake-related control mechanisms. Neurofeedback training might support therapeutic strategies aiming at improved self-control in obesity, although the respective contributions of area-specific mechanisms and general regulation effects are in need of further investigation.
000861154 536__ $$0G:(DE-HGF)POF3-572$$a572 - (Dys-)function and Plasticity (POF3-572)$$cPOF3-572$$fPOF III$$x0
000861154 588__ $$aDataset connected to CrossRef
000861154 7001_ $$0P:(DE-HGF)0$$aVeit, Ralf$$b1
000861154 7001_ $$0P:(DE-HGF)0$$aSpetter, Maartje S.$$b2
000861154 7001_ $$0P:(DE-HGF)0$$aGünther, Astrid$$b3
000861154 7001_ $$0P:(DE-HGF)0$$aRina, Andriani$$b4
000861154 7001_ $$0P:(DE-HGF)0$$aLührs, Michael$$b5
000861154 7001_ $$0P:(DE-HGF)0$$aBirbaumer, Niels$$b6
000861154 7001_ $$0P:(DE-HGF)0$$aPreissl, Hubert$$b7$$eCorresponding author
000861154 7001_ $$0P:(DE-HGF)0$$aHallschmid, Manfred$$b8
000861154 773__ $$0PERI:(DE-600)1471418-8$$a10.1016/j.neuroimage.2019.02.033$$gp. S1053811919301272$$p596-609$$tNeuroImage$$v191$$x1053-8119$$y2019
000861154 8564_ $$uhttps://juser.fz-juelich.de/record/861154/files/Kohl_2019_Post%20Print_NeuroImage_Real_time%20fMRI%20neurofeedback%20training%20to%20improve%20eating%20behavior.pdf$$yPublished on 2019-02-21. Available in OpenAccess from 2020-02-21.
000861154 8564_ $$uhttps://juser.fz-juelich.de/record/861154/files/Kohl_2019_Post%20Print_NeuroImage_Real_time%20fMRI%20neurofeedback%20training%20to%20improve%20eating%20behavior.pdf?subformat=pdfa$$xpdfa$$yPublished on 2019-02-21. Available in OpenAccess from 2020-02-21.
000861154 909CO $$ooai:juser.fz-juelich.de:861154$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000861154 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)173070$$aForschungszentrum Jülich$$b0$$kFZJ
000861154 9131_ $$0G:(DE-HGF)POF3-572$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$v(Dys-)function and Plasticity$$x0
000861154 9141_ $$y2019
000861154 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000861154 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000861154 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000861154 915__ $$0StatID:(DE-HGF)0530$$2StatID$$aEmbargoed OpenAccess
000861154 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNEUROIMAGE : 2017
000861154 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000861154 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000861154 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000861154 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000861154 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bNEUROIMAGE : 2017
000861154 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000861154 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000861154 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000861154 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000861154 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000861154 920__ $$lyes
000861154 9201_ $$0I:(DE-Juel1)INM-3-20090406$$kINM-3$$lKognitive Neurowissenschaften$$x0
000861154 980__ $$ajournal
000861154 980__ $$aVDB
000861154 980__ $$aUNRESTRICTED
000861154 980__ $$aI:(DE-Juel1)INM-3-20090406
000861154 9801_ $$aFullTexts