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@ARTICLE{Kohl:861154,
      author       = {Kohl, Simon H. and Veit, Ralf and Spetter, Maartje S. and
                      Günther, Astrid and Rina, Andriani and Lührs, Michael and
                      Birbaumer, Niels and Preissl, Hubert and Hallschmid,
                      Manfred},
      title        = {{R}eal-time f{MRI} neurofeedback training to improve eating
                      behavior by self-regulation of the dorsolateral prefrontal
                      cortex: {A} randomized controlled trial in overweight and
                      obese subjects},
      journal      = {NeuroImage},
      volume       = {191},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {FZJ-2019-01709},
      pages        = {596-609},
      year         = {2019},
      abstract     = {Obesity is associated with altered responses to food
                      stimuli in prefrontal brain networks that mediate inhibitory
                      control of ingestive behavior. In particular, activity of
                      the dorsolateral prefrontal cortex (dlPFC) is reduced in
                      obese compared to normal-weight subjects and has been linked
                      to the success of weight-loss dietary interventions. In a
                      randomized controlled trial in overweight/obese subjects, we
                      investigated the effect on eating behavior of volitional
                      up-regulation of dlPFC activity via real-time functional
                      magnetic resonance imaging (fMRI) neurofeedback
                      training.Thirty-eight overweight or obese subjects (BMI
                      25–40 kg/m2) took part in fMRI neurofeedback training
                      with the aim of increasing activity of the left dlPFC (dlPFC
                      group; n = 17) or of the visual cortex (VC/control
                      group; n = 21). Participants were blinded to group
                      assignment. The training session took place on a single day
                      and included three training runs of six trials of
                      up-regulation and passive viewing. Food appraisal and snack
                      intake were assessed at screening, after training, and in a
                      follow-up session four weeks later.Participants of both
                      groups succeeded in up-regulating activity of the targeted
                      brain area. However, participants of the control group also
                      showed increased left dlPFC activity during up-regulation.
                      Functional connectivity between dlPFC and ventromedial PFC,
                      an area that processes food value, was generally increased
                      during up-regulation compared to passive viewing. At
                      follow-up compared to baseline, both groups rated pictures
                      of high-, but not low-calorie foods as less palatable and
                      chose them less frequently. Actual snack intake remained
                      unchanged but palatability and choice ratings for chocolate
                      cookies decreased after training.We demonstrate that one
                      session of fMRI neurofeedback training enables individuals
                      with increased body weight to up-regulate activity of the
                      left dlPFC. Behavioral effects were observed in both groups,
                      which might have been due to dlPFC co-activation in the
                      control group and, in addition, unspecific training effects.
                      Improved dlPFC-vmPFC functional connectivity furthermore
                      suggested enhanced food intake-related control mechanisms.
                      Neurofeedback training might support therapeutic strategies
                      aiming at improved self-control in obesity, although the
                      respective contributions of area-specific mechanisms and
                      general regulation effects are in need of further
                      investigation.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30798010},
      UT           = {WOS:000462145700052},
      doi          = {10.1016/j.neuroimage.2019.02.033},
      url          = {https://juser.fz-juelich.de/record/861154},
}