TY  - JOUR
AU  - Sommerauer, Michael
AU  - Galldiks, Norbert
AU  - Barbe, Michael T.
AU  - Stoffels, Gabriele
AU  - Willuweit, Antje
AU  - Coenen, Heinrich Hubert
AU  - Schroeter, Michael
AU  - Timmermann, Lars
AU  - Fink, Gereon R.
AU  - Langen, Karl-Josef
TI  - Cis-4-[18F]fluoro-D-proline detects neurodegeneration in patients with akinetic-rigid parkinsonism
JO  - Nuclear medicine communications
VL  - 40
IS  - 4
SN  - 0143-3636
CY  - [s.l.]
PB  - Ovid
M1  - FZJ-2019-01732
SP  - 383-387
PY  - 2019
AB  - Objectives This study aimed to investigate whether the amino acid PET tracer cis-4-[18F]fluoro-D-proline [D-cis-[18F]FPro] shows increased uptake in the basal ganglia of patients with neurodegenerative akinetic-rigid parkinsonism. D-Cis-[18F]FPro is a sensitive PET tracer for inflammation-associated neurodegeneration in animal models. We hypothesized that D-cis-[18F]FPro might also be a sensitive marker of alterations of the basal ganglia in parkinsonian syndromes.Participants and methods Ten patients with neurodegenerative akinetic-rigid parkinsonism (five with idiopathic Parkinson’s disease and five with atypical parkinsonian syndromes) were imaged with D-cis-[18F]FPro and compared with 13 patients with brain tumors who had no basal ganglia involvement. PET images 20–50 min after injection were evaluated and tracer uptake in the basal ganglia was quantified using volume-of-interest analysis with basal ganglia to background ratios. The severity of disease was assessed with unified Parkinson’s disease rating scale III and correlated with D-cis-[18F]FPro uptake.Results In patients with parkinsonism, volume-of-interest analysis showed mild, but significantly increased D-cis-[18F]FPro uptake in the basal ganglia, pronounced in the lenticular nucleus. Disease severity correlated with D-cis-[18F]FPro uptake in the right pallidum (r=−0.687, P=0.041).Conclusion Data suggest that D-cis-[18F]FPro is a sensitive marker of inflammation-associated degenerative processes in parkinsonian syndromes.
LB  - PUB:(DE-HGF)16
C6  - pmid:30875335
UR  - <Go to ISI:>//WOS:000462182500012
DO  - DOI:10.1097/MNM.0000000000000982
UR  - https://juser.fz-juelich.de/record/861200
ER  -