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@ARTICLE{Sommerauer:861200,
      author       = {Sommerauer, Michael and Galldiks, Norbert and Barbe,
                      Michael T. and Stoffels, Gabriele and Willuweit, Antje and
                      Coenen, Heinrich Hubert and Schroeter, Michael and
                      Timmermann, Lars and Fink, Gereon R. and Langen, Karl-Josef},
      title        = {{C}is-4-[18{F}]fluoro-{D}-proline detects neurodegeneration
                      in patients with akinetic-rigid parkinsonism},
      journal      = {Nuclear medicine communications},
      volume       = {40},
      number       = {4},
      issn         = {0143-3636},
      address      = {[s.l.]},
      publisher    = {Ovid},
      reportid     = {FZJ-2019-01732},
      pages        = {383-387},
      year         = {2019},
      abstract     = {Objectives This study aimed to investigate whether the
                      amino acid PET tracer cis-4-[18F]fluoro-D-proline
                      [D-cis-[18F]FPro] shows increased uptake in the basal
                      ganglia of patients with neurodegenerative akinetic-rigid
                      parkinsonism. D-Cis-[18F]FPro is a sensitive PET tracer for
                      inflammation-associated neurodegeneration in animal models.
                      We hypothesized that D-cis-[18F]FPro might also be a
                      sensitive marker of alterations of the basal ganglia in
                      parkinsonian syndromes.Participants and methods Ten patients
                      with neurodegenerative akinetic-rigid parkinsonism (five
                      with idiopathic Parkinson’s disease and five with atypical
                      parkinsonian syndromes) were imaged with D-cis-[18F]FPro and
                      compared with 13 patients with brain tumors who had no basal
                      ganglia involvement. PET images 20–50 min after
                      injection were evaluated and tracer uptake in the basal
                      ganglia was quantified using volume-of-interest analysis
                      with basal ganglia to background ratios. The severity of
                      disease was assessed with unified Parkinson’s disease
                      rating scale III and correlated with D-cis-[18F]FPro
                      uptake.Results In patients with parkinsonism,
                      volume-of-interest analysis showed mild, but significantly
                      increased D-cis-[18F]FPro uptake in the basal ganglia,
                      pronounced in the lenticular nucleus. Disease severity
                      correlated with D-cis-[18F]FPro uptake in the right pallidum
                      (r=−0.687, P=0.041).Conclusion Data suggest that
                      D-cis-[18F]FPro is a sensitive marker of
                      inflammation-associated degenerative processes in
                      parkinsonian syndromes.},
      cin          = {INM-3 / INM-4 / INM-5},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406 /
                      I:(DE-Juel1)INM-5-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30875335},
      UT           = {WOS:000462182500012},
      doi          = {10.1097/MNM.0000000000000982},
      url          = {https://juser.fz-juelich.de/record/861200},
}