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000861352 1001_ $$0P:(DE-HGF)0$$aGeinguenaud, Frédéric$$b0
000861352 245__ $$aConformational transition of DNA bound to Hfq probed by infrared spectroscopy
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000861352 520__ $$aHfq is a bacterial protein involved in RNA metabolism. Besides this, Hfq's role in DNA restructuring has also been suggested. Since this mechanism remains unclear, we examined the DNA conformation upon Hfq binding by combining vibrational spectroscopy and neutron scattering. Our analysis reveals that Hfq, which preferentially interacts with deoxyadenosine rich sequences, induces partial opening of dA–dT sequences accompanied by sugar repuckering of the dA strand and hence results in a heteronomous A/B duplex. Sugar repuckering is probably correlated with a global dehydration of the complex. By taking into account Hfq's preferential binding to A-tracts, which are commonly found in promoters, potential biological implications of Hfq binding to DNA are discussed.
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000861352 7001_ $$0P:(DE-Juel1)166168$$aCalandrini, Vania$$b1$$ufzj
000861352 7001_ $$0P:(DE-HGF)0$$aTeixeira, José$$b2
000861352 7001_ $$0P:(DE-HGF)0$$aMayer, Claudine$$b3
000861352 7001_ $$0P:(DE-HGF)0$$aLiquier, Jean$$b4
000861352 7001_ $$0P:(DE-HGF)0$$aLavelle, Christophe$$b5
000861352 7001_ $$0P:(DE-HGF)0$$aArluison, Véronique$$b6$$eCorresponding author
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