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@ARTICLE{Holiga:861383,
      author       = {Holiga, Štefan and Hipp, Joerg F. and Chatham, Christopher
                      H. and Garces, Pilar and Spooren, Will and D’Ardhuy,
                      Xavier Liogier and Bertolino, Alessandro and Bouquet,
                      Céline and Buitelaar, Jan K. and Bours, Carsten and Rausch,
                      Annika and Oldehinkel, Marianne and Bouvard, Manuel and
                      Amestoy, Anouck and Caralp, Mireille and Gueguen, Sonia and
                      Ly-Le Moal, Myriam and Houenou, Josselin and Beckmann,
                      Christian F. and Loth, Eva and Murphy, Declan and Charman,
                      Tony and Tillmann, Julian and Laidi, Charles and Delorme,
                      Richard and Beggiato, Anita and Gaman, Alexandru and Scheid,
                      Isabelle and Leboyer, Marion and d’Albis, Marc-Antoine and
                      Sevigny, Jeff and Czech, Christian and Bolognani, Federico
                      and Honey, Garry D. and Dukart, Juergen},
      title        = {{P}atients with autism spectrum disorders display
                      reproducible functional connectivity alterations},
      journal      = {Science translational medicine},
      volume       = {11},
      number       = {481},
      issn         = {1946-6242},
      address      = {Washington, DC},
      publisher    = {AAAS},
      reportid     = {FZJ-2019-01861},
      pages        = {eaat9223},
      year         = {2019},
      abstract     = {Despite the high clinical burden, little is known about
                      pathophysiology underlying autism spectrum disorder(ASD).
                      Recent resting-state functional magnetic resonance imaging
                      (rs-fMRI) studies have found atypical synchro-nization of
                      brain activity in ASD. However, no consensus has been
                      reached on the nature and clinical relevance ofthese
                      alterations. Here, we addressed these questions in four
                      large ASD cohorts. Using rs-fMRI, we identified func-tional
                      connectivity alterations associated with ASD. We tested for
                      associations of these imaging phenotypes withclinical and
                      demographic factors such as age, sex, medication status, and
                      clinical symptom severity. Our resultsshowed reproducible
                      patterns of ASD-associated functional hyper- and
                      hypoconnectivity. Hypoconnectivity wasprimarily restricted
                      to sensory-motor regions, whereas hyperconnectivity hubs
                      were predominately located inprefrontal and parietal
                      cortices. Shifts in cortico-cortical between-network
                      connectivity from outside to withinthe identified regions
                      were shown to be a key driver of these abnormalities. This
                      reproducible pathophysiologicalphenotype was partially
                      associated with core ASD symptoms related to communication
                      and daily living skills andwas not affected by age, sex, or
                      medication status. Although the large effect sizes in
                      standardized cohorts areencouraging with respect to
                      potential application as a treatment and for patient
                      stratification, the moderate linkto clinical symptoms and
                      the large overlap with healthy controls currently limit the
                      usability of identified altera-tions as diagnostic or
                      efficacy readout.},
      cin          = {INM-7},
      ddc          = {500},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30814340},
      UT           = {WOS:000460307000002},
      doi          = {10.1126/scitranslmed.aat9223},
      url          = {https://juser.fz-juelich.de/record/861383},
}