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@ARTICLE{Giehl:861385,
      author       = {Giehl, Kathrin and Tahmasian, Masoud and Eickhoff, Simon
                      and van Eimeren, Thilo},
      title        = {{I}maging executive functions in {P}arkinson's disease:
                      {A}n activation likelihood estimation meta-analysis},
      journal      = {Parkinsonism $\&$ related disorders},
      volume       = {63},
      issn         = {1353-8020},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2019-01863},
      pages        = {137-142},
      year         = {2019},
      abstract     = {INTRODUCTION:Executive dysfunction is a common and early
                      cognitive symptom in Parkinson's disease (PD) with a
                      detrimental effect on quality of life of patients and their
                      care givers. Thus, a number of neuroimaging studies
                      investigated the underlying neural correlates of such an
                      impairment. Results of individual studies, however, are not
                      univocal in terms of location and directionality of
                      associated functional brain changes.OBJECTIVE:To assess
                      convergence of abnormal brain activation in patients with PD
                      during the performance of tasks probing executive functions
                      (EF).METHODS:We screened the functional imaging literature
                      on EF in PD using the PubMed database, extracted reported
                      stereotactic data and tested for convergence of deviant
                      neural activation in patients with PD when compared to
                      healthy controls (HC) using a coordinate-based activation
                      likelihood estimation approach.RESULTS:We identified 22
                      eligible papers from which the main proportion was targeted
                      at the investigation of working memory encompassing 354
                      patients and 306 HC. Surprisingly, no significant converging
                      aberrant activation between HC and patients (ON, OFF or ON +
                      OFF medication, respectively) could be observed when
                      controlling for multiple comparisons using family-wise error
                      correction on cluster-level.CONCLUSION:We conclude that
                      there is currently not enough available evidence to pinpoint
                      a specific neural correlate associated with executive
                      dysfunction in PD. This might be due to the small number of
                      studies performed and their methodical inconsistency.
                      Therefore, it is important to conduct more research
                      regarding functional brain changes associated with EF in
                      these patients using more consistent frameworks and bigger
                      samples.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30833230},
      UT           = {WOS:000482247500022},
      doi          = {10.1016/j.parkreldis.2019.02.015},
      url          = {https://juser.fz-juelich.de/record/861385},
}