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000861491 1001_ $$0P:(DE-Juel1)141935$$aRosenberg, Jessica$$b0$$eCorresponding author
000861491 245__ $$aWhat magnetic resonance imaging reveals – A systematic review of the relationship between type II diabetes and associated brain distortions of structure and cognitive functioning
000861491 260__ $$aOrlando, Fla.$$bAcademic Press$$c2019
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000861491 520__ $$aDue to its increasing prevalence, Type 2 diabetes mellitus (T2DM) represents a major health challenge for modern society. Despite it being of fundamental interest, only a few MRI studies have conducted statistical analyses to draw scientifically valid conclusions about the complex interplay of T2DM and its associated clinical, structural, functional, metabolite, as well as cognitive distortions. Therefore, a systematic review of 68 manuscripts, following the PRISMA guidelines, was conducted. Notably, although the associations between imaging, clinical, and cognitive variables are not fully homogeneous, findings show a clear trend towards a link between altered brain structure and a decline in cognitive processing ability. The results of the review highlight the heterogeneity of the methods used across manuscripts in terms of assessed clinical variables, imaging, and data analysis methods. This is particularly significant as, if the subjects’ criteria are not carefully considered, results are easily prone to confounding factors.
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000861491 7001_ $$0P:(DE-HGF)0$$aLechea, Nazim$$b1
000861491 7001_ $$0P:(DE-HGF)0$$aPentang, Gael N.$$b2
000861491 7001_ $$0P:(DE-Juel1)131794$$aShah, N. J.$$b3$$ufzj
000861491 773__ $$0PERI:(DE-600)1467532-8$$a10.1016/j.yfrne.2018.10.001$$gVol. 52, p. 79 - 112$$p79 - 112$$tFrontiers in neuroendocrinology$$v52$$x0091-3022$$y2019
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