TY  - JOUR
AU  - Rosenberg, Jessica
AU  - Lechea, Nazim
AU  - Pentang, Gael N.
AU  - Shah, N. J.
TI  - What magnetic resonance imaging reveals – A systematic review of the relationship between type II diabetes and associated brain distortions of structure and cognitive functioning
JO  - Frontiers in neuroendocrinology
VL  - 52
SN  - 0091-3022
CY  - Orlando, Fla.
PB  - Academic Press
M1  - FZJ-2019-01952
SP  - 79 - 112
PY  - 2019
AB  - Due to its increasing prevalence, Type 2 diabetes mellitus (T2DM) represents a major health challenge for modern society. Despite it being of fundamental interest, only a few MRI studies have conducted statistical analyses to draw scientifically valid conclusions about the complex interplay of T2DM and its associated clinical, structural, functional, metabolite, as well as cognitive distortions. Therefore, a systematic review of 68 manuscripts, following the PRISMA guidelines, was conducted. Notably, although the associations between imaging, clinical, and cognitive variables are not fully homogeneous, findings show a clear trend towards a link between altered brain structure and a decline in cognitive processing ability. The results of the review highlight the heterogeneity of the methods used across manuscripts in terms of assessed clinical variables, imaging, and data analysis methods. This is particularly significant as, if the subjects’ criteria are not carefully considered, results are easily prone to confounding factors.
LB  - PUB:(DE-HGF)16
C6  - pmid:30392901
UR  - <Go to ISI:>//WOS:000459526300007
DO  - DOI:10.1016/j.yfrne.2018.10.001
UR  - https://juser.fz-juelich.de/record/861491
ER  -