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@ARTICLE{Kharabian:861499,
      author       = {Kharabian, Shahrzad and Eickhoff, Simon and Hoffstaedter,
                      Felix and GENON, Sarah},
      title        = {{E}mpirical examination of the replicability of
                      associations between brain structure and psychological
                      variables},
      journal      = {eLife},
      volume       = {8},
      issn         = {2050-084X},
      address      = {Cambridge},
      publisher    = {eLife Sciences Publications},
      reportid     = {FZJ-2019-01960},
      pages        = {e43464},
      year         = {2019},
      note         = {This work was supported by the Deutsche
                      Forschungsgemeinschaft (DFG, GE 2835/1-1, EI 816/4-1), the
                      Helmholtz Portfolio Theme ‘Supercomputing and Modelling
                      for the Human Brain’ and the European Union’s Horizon
                      2020 Research and Innovation Programme under Grant Agreement
                      No. 720270 (HBP SGA1) and Grant Agreement No. 785907 (HBP
                      SGA2).},
      abstract     = {Linking interindividual differences in psychological
                      phenotype to variations in brain structure is an old dream
                      for psychology and a crucial question for cognitive
                      neurosciences. Yet, replicability of the previously-reported
                      'structural brain behavior' (SBB)-associations has been
                      questioned, recently. Here, we conducted an empirical
                      investigation, assessing replicability of SBB among heathy
                      adults. For a wide range of psychological measures, the
                      replicability of associations with gray matter volume was
                      assessed. Our results revealed that among healthy
                      individuals 1) finding an association between performance at
                      standard psychological tests and brain morphology is
                      relatively unlikely 2) significant associations, found using
                      an exploratory approach, have overestimated effect sizes and
                      3) can hardly be replicated in an independent sample. After
                      considering factors such as sample size and comparing our
                      findings with more replicable SBB-associations in a clinical
                      cohort and replicable associations between brain structure
                      and non-psychological phenotype, we discuss the potential
                      causes and consequences of these findings.},
      cin          = {INM-7},
      ddc          = {600},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {574 - Theory, modelling and simulation (POF3-574) / SMHB -
                      Supercomputing and Modelling for the Human Brain
                      (HGF-SMHB-2013-2017) / HBP SGA1 - Human Brain Project
                      Specific Grant Agreement 1 (720270) / HBP SGA2 - Human Brain
                      Project Specific Grant Agreement 2 (785907)},
      pid          = {G:(DE-HGF)POF3-574 / G:(DE-Juel1)HGF-SMHB-2013-2017 /
                      G:(EU-Grant)720270 / G:(EU-Grant)785907},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30864950},
      UT           = {WOS:000466010800001},
      doi          = {10.7554/eLife.43464},
      url          = {https://juser.fz-juelich.de/record/861499},
}