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@ARTICLE{Chen:861567,
      author       = {Chen, Zhaolin and Jamadar, Sharna D. and Li, Shenpeng and
                      Sforazzini, Francesco and Baran, Jakub and Ferris, Nicholas
                      and Shah, N. J. and Egan, Gary F.},
      title        = {{F}rom simultaneous to synergistic {MR}-{PET} brain
                      imaging: {A} review of hybrid {MR}-{PET} imaging
                      methodologies},
      journal      = {Human brain mapping},
      volume       = {39},
      number       = {12},
      issn         = {1065-9471},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {FZJ-2019-02018},
      pages        = {5126 - 5144},
      year         = {2018},
      abstract     = {Simultaneous Magnetic Resonance Imaging (MRI) and Positron
                      Emission Tomography (PET) scanning is a recent major
                      development in biomedical imaging. The full integration of
                      the PET detector ring and electronics within the MR system
                      has been a technologically challenging design to develop but
                      provides capacity for simultaneous imaging and the potential
                      for new diagnostic and research capability. This article
                      reviews state‐of‐the‐art MR‐PET hardware and
                      software, and discusses future developments focusing on
                      neuroimaging methodologies for MR‐PET scanning. We
                      particularly focus on the methodologies that lead to an
                      improved synergy between MRI and PET, including optimal data
                      acquisition, PET attenuation and motion correction, and
                      joint image reconstruction and processing methods based on
                      the underlying complementary and mutual information. We
                      further review the current and potential future applications
                      of simultaneous MR‐PET in both systems neuroscience and
                      clinical neuroimaging research. We demonstrate a
                      simultaneous data acquisition protocol to highlight new
                      applications of MR‐PET neuroimaging research studies.},
      cin          = {INM-4 / INM-11 / JARA-BRAIN},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-11-20170113 /
                      $I:(DE-82)080010_20140620$},
      pnm          = {573 - Neuroimaging (POF3-573)},
      pid          = {G:(DE-HGF)POF3-573},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:30076750},
      UT           = {WOS:000449673400040},
      doi          = {10.1002/hbm.24314},
      url          = {https://juser.fz-juelich.de/record/861567},
}