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000861576 0247_ $$2doi$$a10.1080/15622975.2018.1428357
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000861576 1001_ $$0P:(DE-HGF)0$$aHildebrandt, Caroline S.$$b0$$eCorresponding author
000861576 245__ $$aNo detectable effects of acute tryptophan depletion on short-term immune system cytokine levels in healthy adults
000861576 260__ $$aAbingdon$$bTaylor & Francis Group$$c2019
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000861576 520__ $$aObjectives: Recent research suggested an influence of diminished central nervous serotonin (5-HT) synthesis on the leptin axis via immunological mechanisms in healthy adult females. However, studies assessing immunological parameters in combination with dietary challenge techniques that impact brain 5-HT synthesis in humans are lacking. Methods: In the present trial, a pilot analysis was conducted on data obtained in healthy adult humans receiving either different dietary acute tryptophan depletion (ATD) challenge or tryptophan (TRP)-balanced control conditions (BAL) to study the effects of reduced central nervous 5-HT synthesis on serum tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β) and IL-6 concentrations. The data of N = 35 healthy adults were analysed who were randomly subjected to one of the following two dietary conditions in a double-blind between-subject approach: (1) The Moja-De ATD challenge (ATD), or (2) TRP-balanced control condition for ATD Moja-De (BAL). Serum concentrations for the assessment of relevant parameters (TNF-α, IL-1β and IL-6) and relevant TRP-related characteristics after the respective challenge procedures were assessed at baseline (T0) and in hourly intervals after administration over a period of 6 h (T1–T6). Results: The ATD condition did not result in significant changes to cytokine concentrations for the entire study sample, or in male and female subgroups. Depletion of CNS 5-HT via dietary TRP depletion appears to have no statistically significant short-term impact on cytokine concentrations in healthy adults. Conclusions: Future research on immunological stressors in combination with challenge techniques will be of value in order to further disentangle the complex interplay between brain 5-HT synthesis and immunological pathways.
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000861576 7001_ $$0P:(DE-HGF)0$$aHelmbold, Katrin$$b1
000861576 7001_ $$0P:(DE-HGF)0$$aLinden, Maike$$b2
000861576 7001_ $$0P:(DE-Juel1)131777$$aLangen, Karl-Josef$$b3$$ufzj
000861576 7001_ $$0P:(DE-HGF)0$$aFilss, C. P.$$b4
000861576 7001_ $$0P:(DE-HGF)0$$aRunions, Kevin C.$$b5
000861576 7001_ $$0P:(DE-HGF)0$$aStewart, Richard M.$$b6
000861576 7001_ $$0P:(DE-HGF)0$$aRao, Pradeep$$b7
000861576 7001_ $$0P:(DE-HGF)0$$aMoore, Julie K.$$b8
000861576 7001_ $$0P:(DE-HGF)0$$aMahfouda, Simone$$b9
000861576 7001_ $$0P:(DE-HGF)0$$aMorandini, Hugo A. E.$$b10
000861576 7001_ $$0P:(DE-HGF)0$$aWong, Janice W. Y.$$b11
000861576 7001_ $$0P:(DE-HGF)0$$aRink, Lothar$$b12
000861576 7001_ $$0P:(DE-HGF)0$$aZepf, Florian D.$$b13
000861576 773__ $$0PERI:(DE-600)2170223-8$$a10.1080/15622975.2018.1428357$$gp. 1 - 8$$n5$$p416-423$$tThe world journal of biological psychiatry$$v20$$x1814-1412$$y2019
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