TY  - JOUR
AU  - Hildebrandt, Caroline S.
AU  - Helmbold, Katrin
AU  - Linden, Maike
AU  - Langen, Karl-Josef
AU  - Filss, C. P.
AU  - Runions, Kevin C.
AU  - Stewart, Richard M.
AU  - Rao, Pradeep
AU  - Moore, Julie K.
AU  - Mahfouda, Simone
AU  - Morandini, Hugo A. E.
AU  - Wong, Janice W. Y.
AU  - Rink, Lothar
AU  - Zepf, Florian D.
TI  - No detectable effects of acute tryptophan depletion on short-term immune system cytokine levels in healthy adults
JO  - The world journal of biological psychiatry
VL  - 20
IS  - 5
SN  - 1814-1412
CY  - Abingdon
PB  - Taylor & Francis Group
M1  - FZJ-2019-02027
SP  - 416-423
PY  - 2019
AB  - Objectives: Recent research suggested an influence of diminished central nervous serotonin (5-HT) synthesis on the leptin axis via immunological mechanisms in healthy adult females. However, studies assessing immunological parameters in combination with dietary challenge techniques that impact brain 5-HT synthesis in humans are lacking. Methods: In the present trial, a pilot analysis was conducted on data obtained in healthy adult humans receiving either different dietary acute tryptophan depletion (ATD) challenge or tryptophan (TRP)-balanced control conditions (BAL) to study the effects of reduced central nervous 5-HT synthesis on serum tumor necrosis factor α (TNF-α), interleukin-1β (IL-1β) and IL-6 concentrations. The data of N = 35 healthy adults were analysed who were randomly subjected to one of the following two dietary conditions in a double-blind between-subject approach: (1) The Moja-De ATD challenge (ATD), or (2) TRP-balanced control condition for ATD Moja-De (BAL). Serum concentrations for the assessment of relevant parameters (TNF-α, IL-1β and IL-6) and relevant TRP-related characteristics after the respective challenge procedures were assessed at baseline (T0) and in hourly intervals after administration over a period of 6 h (T1–T6). Results: The ATD condition did not result in significant changes to cytokine concentrations for the entire study sample, or in male and female subgroups. Depletion of CNS 5-HT via dietary TRP depletion appears to have no statistically significant short-term impact on cytokine concentrations in healthy adults. Conclusions: Future research on immunological stressors in combination with challenge techniques will be of value in order to further disentangle the complex interplay between brain 5-HT synthesis and immunological pathways.
LB  - PUB:(DE-HGF)16
C6  - pmid:29353534
UR  - <Go to ISI:>//WOS:000476565200008
DO  - DOI:10.1080/15622975.2018.1428357
UR  - https://juser.fz-juelich.de/record/861576
ER  -